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Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?

Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?

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APELL, Hans-Jürgen, Anna DILLER, 2002. Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?. In: FEBS Letters. 532(1-2), pp. 198-202. ISSN 0014-5793

@article{Apell2002obscu-7883, title={Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?}, year={2002}, doi={10.1016/S0014-5793(02)03675-X}, number={1-2}, volume={532}, issn={0014-5793}, journal={FEBS Letters}, pages={198--202}, author={Apell, Hans-Jürgen and Diller, Anna} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7883"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:38:15Z</dcterms:available> <dc:format>application/pdf</dc:format> <dcterms:title>Do H+ ions obscure electrogenic Na+ and K+ binding in the E1 state of the Na,K-ATPase?</dcterms:title> <dc:creator>Apell, Hans-Jürgen</dc:creator> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:creator>Diller, Anna</dc:creator> <dcterms:abstract xml:lang="eng">In contrast to other P-type ATPases, the Na,K-ATPase binding and release of ions on the cytoplasmic side, to the state called E1, is not electrogenic with the exception of the third Na+. Since the high-resolution structure of the closely related SR Ca-ATPase in state E1 revealed the ion-binding sites deep inside the transmembrane part of the protein, the missing electrogenicity in state E1 can be explained by an obscuring counter-movement of H+ ions. Evidence for such a mechanism is presented by analysis of pH effects of Na+ and K+ binding and by electrogenic H+ movements in the E1 conformation of the Na,K-ATPase.</dcterms:abstract> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7883"/> <dc:language>eng</dc:language> <dc:contributor>Diller, Anna</dc:contributor> <dc:contributor>Apell, Hans-Jürgen</dc:contributor> <dcterms:bibliographicCitation>First publ. in: FEBS Letters 532 (2002), pp. 198-202</dcterms:bibliographicCitation> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:38:15Z</dc:date> <dcterms:issued>2002</dcterms:issued> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

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