Mechanism of hypoglycaemic action of methylenecyclopropylglycine


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MELDE, Klaus, Hermann BUETTNER, Wolfgang BOSCHERT, Horst P. O. WOLF, Sandro GHISLA, 1989. Mechanism of hypoglycaemic action of methylenecyclopropylglycine. In: Biochemical Journal. 259(3), pp. 921-924. ISSN 0264-6021. eISSN 1470-8728

@article{Melde1989Mecha-7877, title={Mechanism of hypoglycaemic action of methylenecyclopropylglycine}, year={1989}, doi={10.1042/bj2590921}, number={3}, volume={259}, issn={0264-6021}, journal={Biochemical Journal}, pages={921--924}, author={Melde, Klaus and Buettner, Hermann and Boschert, Wolfgang and Wolf, Horst P. O. and Ghisla, Sandro} }

<rdf:RDF xmlns:rdf="" xmlns:bibo="" xmlns:dc="" xmlns:dcterms="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:issued>1989</dcterms:issued> <dcterms:rights rdf:resource=""/> <dc:contributor>Wolf, Horst P. O.</dc:contributor> <dc:contributor>Melde, Klaus</dc:contributor> <dc:contributor>Buettner, Hermann</dc:contributor> <dcterms:available rdf:datatype="">2011-03-24T17:38:13Z</dcterms:available> <dc:creator>Wolf, Horst P. O.</dc:creator> <dc:contributor>Boschert, Wolfgang</dc:contributor> <bibo:uri rdf:resource=""/> <dcterms:title>Mechanism of hypoglycaemic action of methylenecyclopropylglycine</dcterms:title> <dc:creator>Ghisla, Sandro</dc:creator> <dc:creator>Melde, Klaus</dc:creator> <dc:format>application/pdf</dc:format> <dcterms:abstract xml:lang="eng">The effects of methylenecyclopropylglycine (MCPG), the lower homologue of hypoglycin A, on starved rats are described. Upon oral ingestion of MCPG (43 mg/kg), a 50% decrease in blood glucose compared with controls was observed after 4 h. The plasma concentrations of lactate and non-esterified fatty acids were substantially increased during this period. The activity of general acyl-CoA dehydrogenase from isolated rat liver mitochondria was not significantly changed. By contrast, the activity of 2-methyl-(branched-chain)-acyl-CoA dehydrogenase decreased by over 80%. The enzyme activity of enoyl-CoA hydratase (crotonase) from pig kidneys decreased by 80% on incubation with the hypothetically toxic metabolite of MCPG, methylenecyclopropylformyl-CoA. These results suggest that the inhibition spectrum of MCPG is quite different from that of hypoglycin A and that similar physiological effects might result from inhibition of different enzymes of β-oxidation, e.g. hypoglycaemia and lacticacidemia. Accumulation of medium-chain acyl-CoA thioesters is probably at the origin of disturbances in pyruvate metabolism.</dcterms:abstract> <dcterms:bibliographicCitation>First publ. in: Biochemical Journal 259 (1989), 3, pp. 921-924</dcterms:bibliographicCitation> <dc:contributor>Ghisla, Sandro</dc:contributor> <dc:date rdf:datatype="">2011-03-24T17:38:13Z</dc:date> <dc:creator>Boschert, Wolfgang</dc:creator> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dc:creator>Buettner, Hermann</dc:creator> </rdf:Description> </rdf:RDF>

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