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Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo

Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo

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Prüfsumme: MD5:5e0e158398085b5397d4560210211630

MENNINI, Tiziana, Massimiliano de PAOLA, Paolo BIGINI, Cristina MASTROTTO, Elena FUMAGALLI, Sara BARBERA, Manuela MENGOZZI, Barbara VIVIANI, Emanuela CORSINI, Marina MARINOVICH, Lars TORUP, Johan van BEEK, Marcel LEIST, Michael BRINES, Anthony CERAMI, Pietro GHEZZI, 2006. Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo. In: Molecular Medicine. 12(7/8), pp. 153-160. ISSN 1076-1551. eISSN 1528-3658

@article{Mennini2006Nonhe-7862, title={Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo}, year={2006}, doi={10.2119/2006-00045.Mennini}, number={7/8}, volume={12}, issn={1076-1551}, journal={Molecular Medicine}, pages={153--160}, author={Mennini, Tiziana and Paola, Massimiliano de and Bigini, Paolo and Mastrotto, Cristina and Fumagalli, Elena and Barbera, Sara and Mengozzi, Manuela and Viviani, Barbara and Corsini, Emanuela and Marinovich, Marina and Torup, Lars and Beek, Johan van and Leist, Marcel and Brines, Michael and Cerami, Anthony and Ghezzi, Pietro} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7862"> <dc:creator>Mennini, Tiziana</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Ghezzi, Pietro</dc:contributor> <dcterms:title>Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo</dcterms:title> <dc:format>application/pdf</dc:format> <dc:creator>Ghezzi, Pietro</dc:creator> <dc:contributor>Barbera, Sara</dc:contributor> <dc:creator>Viviani, Barbara</dc:creator> <dc:contributor>Mengozzi, Manuela</dc:contributor> <dc:creator>Torup, Lars</dc:creator> <dc:creator>Brines, Michael</dc:creator> <dc:contributor>Bigini, Paolo</dc:contributor> <dc:creator>Fumagalli, Elena</dc:creator> <dc:creator>Beek, Johan van</dc:creator> <dc:contributor>Beek, Johan van</dc:contributor> <dc:language>eng</dc:language> <dc:creator>Barbera, Sara</dc:creator> <dc:contributor>Mastrotto, Cristina</dc:contributor> <dc:creator>Paola, Massimiliano de</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:contributor>Leist, Marcel</dc:contributor> <dc:contributor>Corsini, Emanuela</dc:contributor> <dc:creator>Cerami, Anthony</dc:creator> <dc:contributor>Paola, Massimiliano de</dc:contributor> <dc:contributor>Marinovich, Marina</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:38:06Z</dcterms:available> <dc:creator>Mengozzi, Manuela</dc:creator> <dc:contributor>Fumagalli, Elena</dc:contributor> <dc:creator>Mastrotto, Cristina</dc:creator> <dc:contributor>Mennini, Tiziana</dc:contributor> <dcterms:issued>2006</dcterms:issued> <dc:contributor>Cerami, Anthony</dc:contributor> <dc:contributor>Brines, Michael</dc:contributor> <dc:contributor>Torup, Lars</dc:contributor> <dc:contributor>Viviani, Barbara</dc:contributor> <dc:creator>Marinovich, Marina</dc:creator> <dcterms:abstract xml:lang="eng">Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the cervical spinal cord of wobbler mice, an animal model of amyotrophic lateral sclerosis, but had no effect on hematocrit values. ASIALO-EPO and CEPO, like the parent compound EPO, protected primary motoneuron cultures from kainate-induced death in vitro. Both EPO receptor and the common CD131 β chain were expressed in cultured motoneurons and in the anterior horn of wobbler mice spinal cord. Our results strongly support a role for the common β chain CD131 in the protective effect of EPO derivatives on motoneuron degeneration. Thus CEPO, which does not bind to the classical homodimeric EPO receptor and is devoid of hematopoietic activity, could be effective in chronic treatment aimed at reducing motoneuron degeneration.</dcterms:abstract> <dc:creator>Corsini, Emanuela</dc:creator> <dc:creator>Bigini, Paolo</dc:creator> <dcterms:bibliographicCitation>First publ. in: Molecular Medicine 12 (2006), 7/8, pp. 153-160</dcterms:bibliographicCitation> <dc:creator>Leist, Marcel</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7862"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:38:06Z</dc:date> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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