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Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury

Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury

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Prüfsumme: MD5:556025832b825100a3d23fa7a17a4147

HÄRTER, Luc, Marius KEEL, Hannes HENTZE, Marcel LEIST, Wolfgang ERTEL, 2001. Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury. In: Journal of Neuroimmunology. 121(1/2), pp. 76-78. ISSN 0165-5728

@article{Harter2001Caspa-7851, title={Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury}, year={2001}, doi={10.1016/S0165-5728(01)00409-X}, number={1/2}, volume={121}, issn={0165-5728}, journal={Journal of Neuroimmunology}, pages={76--78}, author={Härter, Luc and Keel, Marius and Hentze, Hannes and Leist, Marcel and Ertel, Wolfgang} }

Hentze, Hannes Keel, Marius Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury deposit-license 2011-03-24T17:38:01Z eng Loss of neurons after traumatic brain injury (TBI) might involve dysregulated apoptosis. Activation of caspase-3 is one hallmark of apoptosis. Therefore, caspase-3 activity (cleavage of DEVD-afc) was measured in cerebrospinal fluid (CSF) samples (n=113) from 27 patients with TBI at day 1 t0 14 after trauma. Caspase-3 activity was detected in 31 (27.4%) CSF samples with highest values (> 5.5 mM/min) seen at day 2 5 after trauma. No caspase-3 activity was found in serum from patients or CSF from controls. The presence of activated caspase-3 in CSF suggests ongoing apoptotic processes during traumatic brain injury. application/pdf Leist, Marcel Keel, Marius Härter, Luc 2011-03-24T17:38:01Z Härter, Luc Hentze, Hannes Ertel, Wolfgang First publ. in: Journal of Neuroimmunology 121 (2001), 1/2, pp. 76-78 Leist, Marcel 2001 Ertel, Wolfgang

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