KOPS - Das Institutionelle Repositorium der Universität Konstanz

The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats

The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:ac14df6e8068bf6b4364849379d3a4a2

RÁSONYI, Thomas, Josef SCHLATTER, Daniel R. DIETRICH, 1999. The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats. In: Toxicology Letters. 104(1-2), pp. 83-92. ISSN 0378-4274. Available under: doi: 10.1016/S0378-4274(98)00347-6

@article{Rasonyi1999alpha-7815, title={The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats}, year={1999}, doi={10.1016/S0378-4274(98)00347-6}, number={1-2}, volume={104}, issn={0378-4274}, journal={Toxicology Letters}, pages={83--92}, author={Rásonyi, Thomas and Schlatter, Josef and Dietrich, Daniel R.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7815"> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:44Z</dcterms:available> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:bibliographicCitation>First publ. in: Toxicology Letters 104 (1999), 1-2, pp. 83-92</dcterms:bibliographicCitation> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7815/1/The_role_of_alpha2u.pdf"/> <dc:contributor>Schlatter, Josef</dc:contributor> <dc:contributor>Rásonyi, Thomas</dc:contributor> <dcterms:issued>1999</dcterms:issued> <dc:creator>Rásonyi, Thomas</dc:creator> <dc:creator>Dietrich, Daniel R.</dc:creator> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7815/1/The_role_of_alpha2u.pdf"/> <dc:rights>deposit-license</dc:rights> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7815"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:44Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>The role of alpha2u-globulin in ochratoxin A induced renal toxicity and tumors in F344 rats</dcterms:title> <dcterms:abstract xml:lang="eng">The mycotoxin ochratoxin A (OTA) was shown to be a potent kidney carcinogen in rats demonstrating a marked sex difference in the response. Compared to female rats, male rats had a 10-fold higher incidence of kidney carcinomas. The objective of this study was to investigate whether this sex difference in tumor response is due to an exacerbation of effect resulting from the interaction of the male rat specific urinary protein α2u-globulin (α2u) with OTA. Male and female rats were treated by oral gavage with OTA (1 mg/kg per day), D-limonene (dL; 1650 mg/kg per day) as a positive control or corn oil for 7 consecutive days. OTA induced severe renal lesions predominantly in the P3 region of the proximal tubules. The lesions consisted of necrotic cells and cell exfoliations. No hyaline droplets were found in the P2 segment following OTA treatment, whereas dL induced the expected accumulation of droplets. The results suggest that OTA induced kidney lesions are in all characteristic points different from the known α2u-nephropathy induced by dL. Based on these experiments the male rat specific protein α2u does not seem to be involved in the mechanism(s) leading to the high tumor incidence observed in OTA exposed male rats.</dcterms:abstract> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:format>application/pdf</dc:format> <dc:creator>Schlatter, Josef</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Dietrich, Daniel R.</dc:contributor> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

The_role_of_alpha2u.pdf 130

Das Dokument erscheint in:

deposit-license Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: deposit-license

KOPS Suche


Stöbern

Mein Benutzerkonto