KOPS - Das Institutionelle Repositorium der Universität Konstanz

Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha induced liver injury through distinct pathways

Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha induced liver injury through distinct pathways

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:ba1703a8530416d02029e2f9e3d40f35

BOHLINGER, Ines, Marcel LEIST, Johannes BARSIG, Stefan UHLIG, Gisa TIEGS, Albrecht WENDEL, 1995. Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha induced liver injury through distinct pathways. In: Hepatology. 22(6), pp. 1829-1837. ISSN 0270-9139. eISSN 1527-3350

@article{Bohlinger1995Inter-7796, title={Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha induced liver injury through distinct pathways}, year={1995}, doi={10.1002/hep.1840220632}, number={6}, volume={22}, issn={0270-9139}, journal={Hepatology}, pages={1829--1837}, author={Bohlinger, Ines and Leist, Marcel and Barsig, Johannes and Uhlig, Stefan and Tiegs, Gisa and Wendel, Albrecht} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7796"> <dc:contributor>Tiegs, Gisa</dc:contributor> <dc:language>eng</dc:language> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:rights>deposit-license</dc:rights> <dcterms:issued>1995</dcterms:issued> <dc:contributor>Wendel, Albrecht</dc:contributor> <dc:creator>Bohlinger, Ines</dc:creator> <dc:contributor>Barsig, Johannes</dc:contributor> <dc:contributor>Uhlig, Stefan</dc:contributor> <dc:creator>Uhlig, Stefan</dc:creator> <dc:creator>Barsig, Johannes</dc:creator> <dc:format>application/pdf</dc:format> <dc:creator>Tiegs, Gisa</dc:creator> <dc:contributor>Leist, Marcel</dc:contributor> <dcterms:title>Interleukin-1 and nitric oxide protect against tumor necrosis factor alpha induced liver injury through distinct pathways</dcterms:title> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7796"/> <dcterms:abstract xml:lang="eng">Mice sensitized with D-galactosamine (GalN) and challenged with recombinant murine tumor necrosis factor α (TNFα) developed severe apoptotic and secondary necrotic liver injury as assessed by histology, measurement of cytosolic DNA fragments, and determination of liver specific enzymes in plasma. Pretreatment with recombinant human interleukin-1β (IL-1) rendered mice insensitive to this TNFα toxicity. Coadministration of the liver-specific transcriptional inhibitor GalN with IL-1 prevented the development of tolerance, implicating de novo synthesis of liver specific proteins in the induction of tolerance. Pretreatment of mice with IL-1 resulted in elevated levels of nitrite/nitrate in serum and in enhanced nitric oxide synthase (NOS) activity in liver cells isolated from these animals. In addition, pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside conferred complete protection against TNFα-induced liver injury in galactosamine-sensitized mice, suggesting a possible link between IL-1- and NO-in-duced protection. However, prevention of NO-synthesis by NG-monomethyl-L-arginine (NMMA) did not abolish IL-1-induced tolerance to TNFα in vivo. Cytotoxicity of TNFα to isolated hepatocytes sensitized with actinomycin D (ActD) was not significantly altered by inhibition of endogenous nitrite release. Also, enhanced NO production elicited in vitro by glycerol trinitrate or ex vivo by pretreatment with IL-1 had no significant effect in this system. We conclude that IL-1- and NO-induced protection of mice against TNFα-mediated liver damage follow distinct pathways.</dcterms:abstract> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:36Z</dcterms:available> <dc:contributor>Bohlinger, Ines</dc:contributor> <dc:creator>Wendel, Albrecht</dc:creator> <dc:creator>Leist, Marcel</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:37:36Z</dc:date> <dcterms:bibliographicCitation>First publ. in: Hepatology 22 (1995), 6, pp. 1829-1837</dcterms:bibliographicCitation> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Bohlinger_I_Hepatology_1995.pdf 312

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto