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Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons

Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons

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FEURSTEIN, Daniel, Julia KLEINTEICH, Alexandra H. HEUSSNER, Kerstin STEMMER, Daniel DIETRICH, 2010. Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons. In: Environmental Health Perspectives. 118(10), pp. 1370-1375. eISSN 0091-6765. Available under: doi: 10.1289/ehp.0901289

@article{Feurstein2010Inves-7712, title={Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons}, year={2010}, doi={10.1289/ehp.0901289}, number={10}, volume={118}, journal={Environmental Health Perspectives}, pages={1370--1375}, author={Feurstein, Daniel and Kleinteich, Julia and Heussner, Alexandra H. and Stemmer, Kerstin and Dietrich, Daniel} }

Dietrich, Daniel First publ. in: Environmental Health Perspectives 118 (2010), 10, pp. 1370-1375 Feurstein, Daniel 2010 Dietrich, Daniel Stemmer, Kerstin Stemmer, Kerstin Heussner, Alexandra H. Kleinteich, Julia deposit-license application/pdf eng Investigation of Microcystin Congener-Dependent Uptake into Primary Murine Neurons Kleinteich, Julia 2011-03-24T17:36:34Z 2011-03-24T17:36:34Z Contamination of natural waters by toxic cyanobacteria is a growing problem worldwide, resulting in serious water pollution and human health hazards. Microcystins (MCs) represent a group of > 80 cyclic heptapeptides, mediating cytotoxicity via specific protein phosphatase (PP) inhibition at equimolar concentrations (comparable toxicodynamics). Because of the structure and size of MCs, active uptake into cells occurs via organic anion-transporting polypeptides (OATP/Oatp), as confirmed for liver-specific human OATP1B1 and OATP1B3, mouse Oatp1b2 (mOatp1b2), skate Oatp1d1, and the more widely distributed OATP1A2 expressed, for example, at the blood-brain barrier. Tissue-specific and cell-type-specific expression of OATP/Oatp transporters and specific transport of MC congeners (toxicokinetics) therefore appear prerequisite for the reported toxic effects in humans and other species upon MC exposure. Beyond hepatotoxicity induced by the MC-LR congener, the effects of other MC congeners, especially neuronal uptake and toxicity, are unknown. Heussner, Alexandra H. Feurstein, Daniel

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