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Calcium in ciliated protozoa : sources, regulation, and calcium-regulated cell functions

Calcium in ciliated protozoa : sources, regulation, and calcium-regulated cell functions


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PLATTNER, Helmut, Norbert KLAUKE, 2001. Calcium in ciliated protozoa : sources, regulation, and calcium-regulated cell functions. In: International Review of Cytologie. 201, pp. 115-208

@article{Plattner2001Calci-7670, title={Calcium in ciliated protozoa : sources, regulation, and calcium-regulated cell functions}, year={2001}, volume={201}, journal={International Review of Cytologie}, pages={115--208}, author={Plattner, Helmut and Klauke, Norbert} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7670"> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:contributor>Klauke, Norbert</dc:contributor> <dc:creator>Klauke, Norbert</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7670"/> <dc:language>eng</dc:language> <dcterms:issued>2001</dcterms:issued> <dcterms:abstract xml:lang="eng">In ciliates, a variety of processes are regulated by Ca2+, e.g., exocytosis, endocytosis, ciliary beat, cell contraction, and nuclear migration. Differential microdomain regulation may occur by activation of specific channels in different cell regions (e.g., voltage-dependent Ca2+ channels in cilia), by local, nonpropagated activation of subplasmalemmal Ca stores (alveolar sacs), by different sensitivity thresholds, and eventually by interplay with additional second messengers (cilia). During stimulus-secretion coupling, Ca2+ as the only known second messenger operates at approximately 5 microM, whereby mobilization from alveolar sacs is superimposed by "store-operated Ca2+ influx" (SOC), to drive exocytotic and endocytotic membrane fusion. (Content discharge requires binding of extracellular Ca2+ to some secretory proteins.) Ca2+ homeostasis is reestablished by binding to cytosolic Ca2+-binding proteins (e.g., calmodulin), by sequestration into mitochondria (perhaps by Ca2+ uniporter) and into endoplasmic reticulum and alveolar sacs (with a SERCA-type pump), and by extrusion via a plasmalemmal Ca2+ pump and a Na+/Ca2+ exchanger. Comparison of free vs total concentration, [Ca2+] vs [Ca], during activation, using time-resolved fluorochrome analysis and X-ray microanalysis, respectively, reveals that altogether activation requires a calcium flux that is orders of magnitude larger than that expected from the [Ca2+] actually required for local activation.</dcterms:abstract> <dcterms:bibliographicCitation>First publ. in: International Review of Cytologie ; 201 (2001). - S. 115-208</dcterms:bibliographicCitation> <dc:creator>Plattner, Helmut</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:14Z</dc:date> <dc:rights>deposit-license</dc:rights> <dc:format>application/pdf</dc:format> <dc:contributor>Plattner, Helmut</dc:contributor> <dcterms:title>Calcium in ciliated protozoa : sources, regulation, and calcium-regulated cell functions</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:14Z</dcterms:available> </rdf:Description> </rdf:RDF>

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