Type of Publication: | Journal article |
URI (citable link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-39296 |
Author: | Rivera-Milla, Eric; Stürmer, Claudia; Málaga-Trillo, Edward |
Year of publication: | 2006 |
Published in: | Cellular and Molecular Life Sciences ; 63 (2006), 3. - pp. 343-357. - ISSN 1420-682X. - eISSN 1420-9071 |
Pubmed ID: | 16389450 |
DOI (citable link): | https://dx.doi.org/10.1007/s00018-005-5434-3 |
Summary: |
Reggies (flotillins) are detergent-resistant microdomains involved in the scaffolding of large heteromeric complexes that signal across the plasma membrane. Based on the presence of an evolutionarily widespread motif, reggies/flotillins have been included within the SPFH (stomatin-prohibitin-flotillin-HflC/K) protein superfamily. To better understand the origin and evolution of reggie/flotillin structure and function, we searched databases for reggie/flotillin and SPFH-like proteins in organisms at the base and beyond the animal kingdom, and used the resulting dataset to compare their structural and functional domains. Our analysis shows that the SPFH grouping has little phylogenetic support, probably due to convergent evolution of its members. We also find that reggie/flotillin homologues are highly conserved among metazoans but are absent in plants, fungi and bacteria, where only proteins with "reggie-like" domains can be found. However, despite their low sequence similarities, reggie/flotillin and "reggie-like" domains appear to subserve related functions, suggesting that their basic biological role was acquired independently during evolution.
|
Subject (DDC): | 570 Biosciences, Biology |
Keywords: | Reggie, flotillin, lipid raft, evolution, oligomerization, SPFH |
Link to License: | Attribution-NonCommercial-NoDerivs 2.0 Generic |
Bibliography of Konstanz: | Yes |
RIVERA-MILLA, Eric, Claudia STÜRMER, Edward MÁLAGA-TRILLO, 2006. Ancient origin of reggie (flotillin), reggie-like, and other lipid-raft proteins : convergent evolution of the SPFH domain. In: Cellular and Molecular Life Sciences. 63(3), pp. 343-357. ISSN 1420-682X. eISSN 1420-9071. Available under: doi: 10.1007/s00018-005-5434-3
@article{RiveraMilla2006Ancie-7666, title={Ancient origin of reggie (flotillin), reggie-like, and other lipid-raft proteins : convergent evolution of the SPFH domain}, year={2006}, doi={10.1007/s00018-005-5434-3}, number={3}, volume={63}, issn={1420-682X}, journal={Cellular and Molecular Life Sciences}, pages={343--357}, author={Rivera-Milla, Eric and Stürmer, Claudia and Málaga-Trillo, Edward} }
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7666"> <dcterms:title>Ancient origin of reggie (flotillin), reggie-like, and other lipid-raft proteins : convergent evolution of the SPFH domain</dcterms:title> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7666/1/114_Ancient_origin_of_reggie_flotillin.pdf"/> <dc:rights>Attribution-NonCommercial-NoDerivs 2.0 Generic</dc:rights> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/2.0/"/> <dc:creator>Rivera-Milla, Eric</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">Reggies (flotillins) are detergent-resistant microdomains involved in the scaffolding of large heteromeric complexes that signal across the plasma membrane. Based on the presence of an evolutionarily widespread motif, reggies/flotillins have been included within the SPFH (stomatin-prohibitin-flotillin-HflC/K) protein superfamily. To better understand the origin and evolution of reggie/flotillin structure and function, we searched databases for reggie/flotillin and SPFH-like proteins in organisms at the base and beyond the animal kingdom, and used the resulting dataset to compare their structural and functional domains. Our analysis shows that the SPFH grouping has little phylogenetic support, probably due to convergent evolution of its members. We also find that reggie/flotillin homologues are highly conserved among metazoans but are absent in plants, fungi and bacteria, where only proteins with "reggie-like" domains can be found. However, despite their low sequence similarities, reggie/flotillin and "reggie-like" domains appear to subserve related functions, suggesting that their basic biological role was acquired independently during evolution.</dcterms:abstract> <dcterms:bibliographicCitation>First publ. in: Cellular and Molecular Life Sciences 63 (2006), 3, pp. 343-357</dcterms:bibliographicCitation> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7666/1/114_Ancient_origin_of_reggie_flotillin.pdf"/> <dc:creator>Málaga-Trillo, Edward</dc:creator> <dcterms:issued>2006</dcterms:issued> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:12Z</dc:date> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Málaga-Trillo, Edward</dc:contributor> <dc:contributor>Stürmer, Claudia</dc:contributor> <dc:format>application/pdf</dc:format> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7666"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:12Z</dcterms:available> <dc:contributor>Rivera-Milla, Eric</dc:contributor> <dc:creator>Stürmer, Claudia</dc:creator> </rdf:Description> </rdf:RDF>
114_Ancient_origin_of_reggie_flotillin.pdf | 688 |