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Diversity and evolution of MHII ß genes in a non-model percid species : the Eurasian perch (Perca fluviatilis L.)

Diversity and evolution of MHII ß genes in a non-model percid species : the Eurasian perch (Perca fluviatilis L.)

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MICHEL, Christian, Louis BERNATCHEZ, Jasminca BEHRMANN-GODEL, 2009. Diversity and evolution of MHII ß genes in a non-model percid species : the Eurasian perch (Perca fluviatilis L.). In: Molecular Immunology. 46(16), pp. 3399-3410. ISSN 0161-5890. eISSN 1872-9142

@article{Michel2009Diver-7662, title={Diversity and evolution of MHII ß genes in a non-model percid species : the Eurasian perch (Perca fluviatilis L.)}, year={2009}, doi={10.1016/j.molimm.2009.07.012}, number={16}, volume={46}, issn={0161-5890}, journal={Molecular Immunology}, pages={3399--3410}, author={Michel, Christian and Bernatchez, Louis and Behrmann-Godel, Jasminca} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7662"> <dc:format>application/pdf</dc:format> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:10Z</dc:date> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7662"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:10Z</dcterms:available> <dc:rights>deposit-license</dc:rights> <dc:creator>Behrmann-Godel, Jasminca</dc:creator> <dcterms:title>Diversity and evolution of MHII ß genes in a non-model percid species : the Eurasian perch (Perca fluviatilis L.)</dcterms:title> <dc:contributor>Bernatchez, Louis</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Molecular Immunology 46 (2009), 16, pp. 3399-3410</dcterms:bibliographicCitation> <dcterms:issued>2009</dcterms:issued> <dcterms:abstract xml:lang="eng">This study provides the first investigation of the diversity, structure, and molecular evolution of MHII ß genes in a non-model percid species - the Eurasian perch (Perca fluviatilis L.). PCR primers developed here were highly specific, and documented a high diversity of the MHII ß1 domain in perch. Our results suggest a minimum of eight MHII ßloci in this species - a finding congruent with several studies suggesting that many Euteleostei posses multiple MHII ß loci. As for other vertebrates, both positive selection and gene-conversion contribute to the reported high allelic diversity. Similarly, the MHII ß1 domain in perch exhibits a characteristic MHC fold known from other vertebrates. In addition, our results suggest some teleost specific differences of the MHII ß1 domain, including: differences in chemical properties of specific amino acids in the ß1 domain, the absence of the tetrapod specific glycolisation signal, and differences in the positions of some of the positively selected codons in the MHII ß1 domain, which are presumably involved in antigen binding. Future studies should investigate the teleost MHII ß genes in more details in order to confirm the suggested differences, and to determine the extent to which these differences prevail in different teleost lineages.</dcterms:abstract> <dc:creator>Bernatchez, Louis</dc:creator> <dc:contributor>Michel, Christian</dc:contributor> <dc:language>eng</dc:language> <dc:contributor>Behrmann-Godel, Jasminca</dc:contributor> <dc:creator>Michel, Christian</dc:creator> </rdf:Description> </rdf:RDF>

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