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Deficient IFN-gamma Expression in Umbilical Cord Blood (UCB) T Cells Can Be Rescued by IFN-gamma-Mediated Increase in NFATc2 Expression

Deficient IFN-gamma Expression in Umbilical Cord Blood (UCB) T Cells Can Be Rescued by IFN-gamma-Mediated Increase in NFATc2 Expression

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KADEREIT, Suzanne, Gwendolyn R. JUNGE, Thomas KLEEN, Margaret M. KOZIK, Beth A. KAMINSKI, Kathleen DAUM-WOODS, Pingfu FU, Magdalena TARY-LEHMANN, Mary J. LAUGHLIN, 2003. Deficient IFN-gamma Expression in Umbilical Cord Blood (UCB) T Cells Can Be Rescued by IFN-gamma-Mediated Increase in NFATc2 Expression. In: Journal of Clinical Immunology. 23(6), pp. 485-497. eISSN 0271-9142

@article{Kadereit2003Defic-7661, title={Deficient IFN-gamma Expression in Umbilical Cord Blood (UCB) T Cells Can Be Rescued by IFN-gamma-Mediated Increase in NFATc2 Expression}, year={2003}, doi={10.1023/B:JOCI.0000010425.30967.0f}, number={6}, volume={23}, journal={Journal of Clinical Immunology}, pages={485--497}, author={Kadereit, Suzanne and Junge, Gwendolyn R. and Kleen, Thomas and Kozik, Margaret M. and Kaminski, Beth A. and Daum-Woods, Kathleen and Fu, Pingfu and Tary-Lehmann, Magdalena and Laughlin, Mary J.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7661"> <dc:creator>Junge, Gwendolyn R.</dc:creator> <dc:contributor>Laughlin, Mary J.</dc:contributor> <dc:format>application/pdf</dc:format> <dc:creator>Kleen, Thomas</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:09Z</dcterms:available> <dcterms:title>Deficient IFN-gamma Expression in Umbilical Cord Blood (UCB) T Cells Can Be Rescued by IFN-gamma-Mediated Increase in NFATc2 Expression</dcterms:title> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Daum-Woods, Kathleen</dc:contributor> <dc:contributor>Junge, Gwendolyn R.</dc:contributor> <dc:contributor>Kadereit, Suzanne</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Journal of Clinical Immunology 23 (2003), 6, pp. 485-497</dcterms:bibliographicCitation> <dcterms:issued>2003</dcterms:issued> <dc:language>eng</dc:language> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7661"/> <dc:contributor>Kozik, Margaret M.</dc:contributor> <dc:creator>Laughlin, Mary J.</dc:creator> <dc:contributor>Tary-Lehmann, Magdalena</dc:contributor> <dc:creator>Kadereit, Suzanne</dc:creator> <dc:creator>Kozik, Margaret M.</dc:creator> <dcterms:abstract xml:lang="eng">Regulation of nuclear factor of activated T cells-c2 (NFATc2) gene expression is not clearly defined. We previously reported reduced NFATc2 protein expression in cord blood T lymphocytes. Here we show that NFATc2 expression in T cells is dependent in part on the presence of IFN-gamma during primary stimulation, as blocking of IFN-gamma blunted NFATc2 protein and mRNA upregulation. Conversely, addition of exogenous IFN-gamma during stimulation resulted in increased expression of NFATc2 in cord blood T lymphocytes. This correlated with rescue of deficient IFN-gamma expression by cord blood T cells. Rescue of IFN-gamma expression in cord blood T cells was dependent on the presence of antigen-presenting cells, as addition of IFN-gamma during stimulation of purified cord blood T cells did not result in an increase of IFN-gamma expression, and depletion of monocytes ablated the rescue of IFN-gamma expression. Our results point to impaired function in the antigen-presenting cell population of cord blood, playing a role in the hyporesponsiveness of T cells.</dcterms:abstract> <dc:creator>Daum-Woods, Kathleen</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:contributor>Fu, Pingfu</dc:contributor> <dc:creator>Tary-Lehmann, Magdalena</dc:creator> <dc:creator>Fu, Pingfu</dc:creator> <dc:creator>Kaminski, Beth A.</dc:creator> <dc:contributor>Kaminski, Beth A.</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:09Z</dc:date> <dc:contributor>Kleen, Thomas</dc:contributor> </rdf:Description> </rdf:RDF>

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