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Overexpression of heat shock protein 70 in R6 / 2 Huntington s disease mice has only modest effects on disease progression

Overexpression of heat shock protein 70 in R6 / 2 Huntington s disease mice has only modest effects on disease progression

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HANSSON, Oskar, Jesper NYLANDSTED, Roger F. CASTILHO, Marcel LEIST, Marja JÄÄTTELÄ, Patrik BRUNDIN, 2003. Overexpression of heat shock protein 70 in R6 / 2 Huntington s disease mice has only modest effects on disease progression. In: Brain Research. 970(1/2), pp. 47-57. ISSN 0006-8993. Available under: doi: 10.1016/S0006-8993(02)04275-0

@article{Hansson2003Overe-7642, title={Overexpression of heat shock protein 70 in R6 / 2 Huntington s disease mice has only modest effects on disease progression}, year={2003}, doi={10.1016/S0006-8993(02)04275-0}, number={1/2}, volume={970}, issn={0006-8993}, journal={Brain Research}, pages={47--57}, author={Hansson, Oskar and Nylandsted, Jesper and Castilho, Roger F. and Leist, Marcel and Jäättelä, Marja and Brundin, Patrik} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7642"> <dc:creator>Castilho, Roger F.</dc:creator> <dc:contributor>Nylandsted, Jesper</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7642"/> <dc:creator>Jäättelä, Marja</dc:creator> <dcterms:bibliographicCitation>First publ. in: Brain Research 970 (2003), 1/2, pp. 47-57</dcterms:bibliographicCitation> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:contributor>Hansson, Oskar</dc:contributor> <dc:contributor>Castilho, Roger F.</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dcterms:issued>2003</dcterms:issued> <dc:creator>Hansson, Oskar</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7642/1/Hanssonetal2003inpress.pdf"/> <dc:contributor>Jäättelä, Marja</dc:contributor> <dc:format>application/pdf</dc:format> <dc:creator>Brundin, Patrik</dc:creator> <dcterms:title>Overexpression of heat shock protein 70 in R6 / 2 Huntington s disease mice has only modest effects on disease progression</dcterms:title> <dcterms:abstract xml:lang="eng">Huntington s disease (HD) is a neurodegenerative disorder caused by expansion of a polyglutamine tract in a protein called huntingtin. The inducible form of heat shock protein 70 (Hsp70) has been shown to reduce polyglutamine-induced toxicity. To investigate if overexpression of Hsp70 can affect disease progression in a mouse model of HD, we crossed R6 / 2 mice, expressing exon 1 of the HD gene with an expanded CAG repeat, with mice overexpressing Hsp70 (both types of transgenic mice were of the CBAxC57BL / 6 strain). The resulting R6 / 2-Hsp70 transgenics exhibited 5- to 15-fold increases in Hsp70 expression in neocortical, hippocampal and basal ganglia regions. This correlated with a delayed loss of body weight compared to R6 / 2 mice. However, the number or size of nuclear inclusions, the loss of brain weight, reduction of striatal volume, reduction in size of striatal projection neurons, downregulation of DARPP-32, development of paw clasping phenotype and early death of the mice were not affected by Hsp70 overexpression. Interestingly, the polyglutamine protein affected the potential rescuing agent, because in older R6 / 2-Hsp70 mice a large proportion of the Hsp70 protein was sequestrated in nuclear inclusions.</dcterms:abstract> <dc:rights>deposit-license</dc:rights> <dc:creator>Nylandsted, Jesper</dc:creator> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:00Z</dc:date> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7642/1/Hanssonetal2003inpress.pdf"/> <dc:contributor>Leist, Marcel</dc:contributor> <dc:contributor>Brundin, Patrik</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:36:00Z</dcterms:available> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Leist, Marcel</dc:creator> <dc:language>eng</dc:language> </rdf:Description> </rdf:RDF>

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