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Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases

Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases

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AGERER, Franziska, Antje MICHEL, Knut OHLSEN, Christof R. HAUCK, 2003. Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases. In: Journal of Biological Chemistry. 278(43), pp. 42524-42531. ISSN 0021-9258. eISSN 1083-351X

@article{Agerer2003Integ-7617, title={Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases}, year={2003}, doi={10.1074/jbc.M302096200}, number={43}, volume={278}, issn={0021-9258}, journal={Journal of Biological Chemistry}, pages={42524--42531}, author={Agerer, Franziska and Michel, Antje and Ohlsen, Knut and Hauck, Christof R.} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7617"> <dcterms:bibliographicCitation>First publ. in: Journal of Biological Chemistry 278 (2003), 43, pp. 42524 42531</dcterms:bibliographicCitation> <dcterms:issued>2003</dcterms:issued> <dcterms:title>Integrin-mediated invasion of Staphylococcus aureus into human cells requires Src family protein-tyrosine kinases</dcterms:title> <dc:contributor>Ohlsen, Knut</dc:contributor> <dc:format>application/pdf</dc:format> <dc:language>eng</dc:language> <dcterms:abstract xml:lang="eng">Staphylococcus aureus, a common cause of nosocomial infections, is able to invade eukaryotic cells by indirectly engaging 1 integrin-containing host receptors, whereas non-pathogenic Staphylococcus carnosus is not invasive. Here, we identify intracellular signals involved in integrin-initiated internalization of S. aureus. In particular, the host cell actin cytoskeleton and Src family protein-tyrosine kinases (PTKs) are essential to mediate S. aureus invasion. Src PTKs are activated in response to pathogenic S. aureus, but not S. carnosus. In addition, pharmacological and genetic interference with Src PTK function reduces bacterial internalization. Importantly, Src PTK-deficient cells are resistant to S. aureus invasion, demonstrating the essentiality of host Src PTKs in integrin-mediated uptake of this pathogen.</dcterms:abstract> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7617"/> <dc:creator>Michel, Antje</dc:creator> <dc:creator>Agerer, Franziska</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:35:49Z</dcterms:available> <dc:contributor>Michel, Antje</dc:contributor> <dc:creator>Hauck, Christof R.</dc:creator> <dc:creator>Ohlsen, Knut</dc:creator> <dc:contributor>Hauck, Christof R.</dc:contributor> <dc:contributor>Agerer, Franziska</dc:contributor> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:35:49Z</dc:date> <dc:rights>deposit-license</dc:rights> </rdf:Description> </rdf:RDF>

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