Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:a3b3a5d01c8a9e980071311acc5552e1

HIRT, Ulrich, Marcel LEIST, 2003. Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells. In: Cell Death and Differentiation. 10(10), pp. 1156-1164. ISSN 1350-9047. eISSN 1476-5403

@article{Hirt2003Rapid-7595, title={Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells}, year={2003}, number={10}, volume={10}, issn={1350-9047}, journal={Cell Death and Differentiation}, pages={1156--1164}, author={Hirt, Ulrich and Leist, Marcel} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7595"> <dc:format>application/pdf</dc:format> <dc:contributor>Hirt, Ulrich</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:35:39Z</dcterms:available> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7595/1/hirt2003.pdf"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Leist, Marcel</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7595/1/hirt2003.pdf"/> <dcterms:issued>2003</dcterms:issued> <dc:rights>deposit-license</dc:rights> <dc:language>eng</dc:language> <dc:creator>Hirt, Ulrich</dc:creator> <dcterms:abstract xml:lang="eng">In pathological situations, different modes of cell death are observed, and information on the role and uptake of nonapoptotic corpses is scarce. Here, we modeled two distinct forms of death in human Jurkat T cells treated with staurosporine: classical apoptosis under normal culture conditions and programmed death with necrotic morphology under ATP-depleting conditions (necPCD). When offered to phagocytes, both types of cell corpses (but not heat-killed unscheduled necrotic cells) reduced the release of the proinflammatory cytokine TNF from the macrophages. The necPCD cells were efficiently engulfed by macrophages and microglia, and from mixtures of necPCD and apoptotic cells macrophages preferentially engulfed the necrotic cells. Using a newly developed assay, we demonstrated that phosphatidylserine is translocated to the surface of such necrotic cells. We demonstrate that this can occur independently of calcium signals, and that surface phosphatidylserine is essential for the uptake of necrotic cells by both human macrophages and murine microglia.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:35:39Z</dc:date> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7595"/> <dcterms:title>Rapid, noninflammatory and PS-dependent phagocytic clearance of necrotic cells</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:creator>Leist, Marcel</dc:creator> <dcterms:bibliographicCitation>First publ. in: Cell Death and Differentiation ; 10 (2003), 10. - pp. 1156-1164</dcterms:bibliographicCitation> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

hirt2003.pdf 163

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto