KOPS - Das Institutionelle Repositorium der Universität Konstanz

Recipient-Specific Tolerance after HLA-Mismatched Umbilical Cord Blood Stem Cell Transplantation

Recipient-Specific Tolerance after HLA-Mismatched Umbilical Cord Blood Stem Cell Transplantation

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:daaa772211bd7ff0651d9a6be26bf63a

KLEEN, Thomas, Suzanne KADEREIT, Laura R. FANNING, Jennifer JAROSCAK, Pingfu FU, Howard J. MEYERSON, Lara KULCHYCKI, Laura F. SLIVKA, Margaret M. KOZIK, Magdalena TARY-LEHMANN, Mary J. LAUGHLIN, 2005. Recipient-Specific Tolerance after HLA-Mismatched Umbilical Cord Blood Stem Cell Transplantation. In: Transplantation. 80(9), pp. 1316-1322. ISSN 0041-1337. Available under: doi: 10.1097/01.tp.0000188172.26531.6f

@article{Kleen2005Recip-7541, title={Recipient-Specific Tolerance after HLA-Mismatched Umbilical Cord Blood Stem Cell Transplantation}, year={2005}, doi={10.1097/01.tp.0000188172.26531.6f}, number={9}, volume={80}, issn={0041-1337}, journal={Transplantation}, pages={1316--1322}, author={Kleen, Thomas and Kadereit, Suzanne and Fanning, Laura R. and Jaroscak, Jennifer and Fu, Pingfu and Meyerson, Howard J. and Kulchycki, Lara and Slivka, Laura F. and Kozik, Margaret M. and Tary-Lehmann, Magdalena and Laughlin, Mary J.} }

Jaroscak, Jennifer 2011-03-24T17:35:15Z Tary-Lehmann, Magdalena Recipient-Specific Tolerance after HLA-Mismatched Umbilical Cord Blood Stem Cell Transplantation Fanning, Laura R. Meyerson, Howard J. application/pdf Kadereit, Suzanne Kulchycki, Lara Slivka, Laura F. deposit-license Tary-Lehmann, Magdalena Laughlin, Mary J. Fu, Pingfu Fanning, Laura R. Kozik, Margaret M. 2011-03-24T17:35:15Z Background: Lower incidence and severity of acute graft versus host disease (GVHD) has been observed in leukemia patients receiving HLA-mismatched umbilical cord (UCB) transplants. However, despite the increased use of UCB in stem cell transplantation, the mechanisms underlying these favorable outcomes are not well delineated.<br /><br />Methods: We analyzed antigen specific lymphocyte responses after transplant to determine whether the decreased allogeneic responsiveness of UCB lymphocytes is attributable to pan-unresponsiveness, lymphocyte repressive or recipient-specific tolerance.<br /><br />Results: Circulating lymphocytes collected early (3 months) after UCB transplant demonstrate a less naive phenotype compared with that in the infused graft. Additionally, after transplant, circulating peripheral blood UCB-derived lymphocytes produced normal levels of interferon-[gamma] and proliferated normally when stimulated with mitogen or third party alloantigen. In contrast, when stimulated with recipient antigen, circulating lymphocytes emerging posttransplant did not proliferate nor produce interferon-[gamma]. Moreover, analysis of interleukin-4 production revealed a Th2 response to recipient antigens. These data indicate early induction of immune tolerance of naive UCB graft lymphocytes with skewing of transplant recipient-specific immune response towards Th2 cytokine profile.<br /><br />Conclusions: UCB graft lymphocyte immune naivety and observed early tolerance induction may contribute to the observed favorable GVHD incidence, despite infusion of HLA mismatch grafts in the unrelated allogeneic setting. Fu, Pingfu Kleen, Thomas 2005 First publ. in: Transplantation 80 (2005), 9, pp. 1316 1322 Kozik, Margaret M. Jaroscak, Jennifer Kadereit, Suzanne Slivka, Laura F. Laughlin, Mary J. Kleen, Thomas Meyerson, Howard J. Kulchycki, Lara eng

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Kleen_et_al.12327_2005.pdf 202

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto