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Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis

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BERLIOCCHI, Laura, Eugenio FAVA, Marcel LEIST, Volker HORVAT, David DINSDALE, David READ, Pierluigi NICOTERA, 2005. Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis. In: The Journal of Cell Biology. 168(4), pp. 607-618. ISSN 0021-9525

@article{Berliocchi2005-02-14Botul-7512, title={Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis}, year={2005}, doi={10.1083/jcb.200406126}, number={4}, volume={168}, issn={0021-9525}, journal={The Journal of Cell Biology}, pages={607--618}, author={Berliocchi, Laura and Fava, Eugenio and Leist, Marcel and Horvat, Volker and Dinsdale, David and Read, David and Nicotera, Pierluigi} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7512"> <dc:contributor>Horvat, Volker</dc:contributor> <dc:format>application/pdf</dc:format> <dcterms:abstract xml:lang="eng">Clostridial neurotoxins are bacterial endopeptidases that cleave the major SNARE proteins in peripheral motorneurons. Here, we show that disruption of synaptic architecture by botulinum neurotoxin C1 (BoNT/C) in central nervous system neurons activates distinct neurodegenerative programs in the axo-dendritic network and in the cell bodies. Neurites degenerate at an early stage by an active caspase-independent fragmentation characterized by segregation of energy competent mitochondria. Later, the cell body mitochondria release cytochrome c, which is followed by caspase activation, apoptotic nuclear condensation, loss of membrane potential, and, finally, cell swelling and lysis. Recognition and scavenging of dying processes by glia also precede the removal of apoptotic cell bodies, in line with a temporal and spatial segregation of different degenerative processes. Our results suggest that, in response to widespread synaptic damage, neurons first dismantle their connections and finally undergo apoptosis, when their spatial relationships are lost.</dcterms:abstract> <dc:contributor>Read, David</dc:contributor> <dc:contributor>Leist, Marcel</dc:contributor> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:35:00Z</dc:date> <dc:creator>Dinsdale, David</dc:creator> <dc:contributor>Dinsdale, David</dc:contributor> <dc:rights>deposit-license</dc:rights> <dc:creator>Horvat, Volker</dc:creator> <dcterms:issued>2005-02-14</dcterms:issued> <dc:creator>Leist, Marcel</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7512"/> <dc:contributor>Nicotera, Pierluigi</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Fava, Eugenio</dc:contributor> <dc:creator>Berliocchi, Laura</dc:creator> <dc:contributor>Berliocchi, Laura</dc:contributor> <dcterms:bibliographicCitation>First publ. in: The Journal of Cell Biology ; 168 (2005), 4. - pp. 607-618</dcterms:bibliographicCitation> <dcterms:title>Botulinum neurotoxin C initiates two different programs for neurite degeneration and neuronal apoptosis</dcterms:title> <dc:creator>Read, David</dc:creator> <dc:creator>Fava, Eugenio</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:35:00Z</dcterms:available> <dc:creator>Nicotera, Pierluigi</dc:creator> </rdf:Description> </rdf:RDF>

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