Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts


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PITTLIK, Silke, Susana DOMINGUES, Axel MEYER, Gerrit BEGEMANN, 2008. Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts. In: Gene Expression Patterns. 8(3), pp. 141-147. ISSN 1567-133X. Available under: doi: 10.1016/j.gep.2007.11.003

@article{Pittlik2008Expre-7446, title={Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts}, year={2008}, doi={10.1016/j.gep.2007.11.003}, number={3}, volume={8}, issn={1567-133X}, journal={Gene Expression Patterns}, pages={141--147}, author={Pittlik, Silke and Domingues, Susana and Meyer, Axel and Begemann, Gerrit} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <bibo:uri rdf:resource=""/> <dc:contributor>Pittlik, Silke</dc:contributor> <dcterms:abstract xml:lang="eng">The vitamin A-derived morphogen retinoic acid (RA) plays important roles during the development of chordate animals. The Aldh1a-family of RA-synthesizing enzymes consists of three members, Aldh1a1 3 (Raldh1 3), that are dynamically expressed throughout development. We have searched the known teleost genomes for the presence of Raldh family members and have found that teleost fish possess orthologs of Aldh1a2 and Aldh1a3 only. Here we describe the expression of aldh1a3 in the previous termzebrafish,next term Danio rerio. Whole mount in situ hybridization shows that aldh1a3 is expressed during eye development in the retina flanking the optic stalks and later is expressed ventrally, opposite the expression domain of aldh1a2. During inner ear morphogenesis, aldh1a3 is expressed in developing sensory epithelia of the cristae and utricular macula and is specifically up-regulated in epithelial projections throughout the formation of the walls of the semicircular canals and endolymphatic duct. In contrast to the mouse inner ear, which expresses all three Raldhs, we find that only aldh1a3 is expressed in the previous termzebrafishnext term otocyst, while aldh1a2 is present in the periotic mesenchyme. During larval stages, additional expression domains of aldh1a3 appear in the anterior pituitary and the swim bladder. Our analyses provide a starting point for genetic studies to examine the role of RA in these organs and emphasize the suitability of the previous termzebrafishnext term inner ear in dissecting the contribution of RA signaling to the development of the vestibular system.</dcterms:abstract> <dcterms:rights rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dcterms:title>Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts</dcterms:title> <dc:format>application/pdf</dc:format> <dc:rights>terms-of-use</dc:rights> <dc:creator>Begemann, Gerrit</dc:creator> <dcterms:hasPart rdf:resource=""/> <dc:language>eng</dc:language> <dc:contributor>Meyer, Axel</dc:contributor> <dc:creator>Meyer, Axel</dc:creator> <dc:creator>Domingues, Susana</dc:creator> <dcterms:bibliographicCitation>First publ. in: Gene Expression Patterns 8 (2008), 3, pp. 141 147</dcterms:bibliographicCitation> <dcterms:available rdf:datatype="">2011-03-24T17:34:29Z</dcterms:available> <dc:contributor>Domingues, Susana</dc:contributor> <dcterms:issued>2008</dcterms:issued> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Pittlik, Silke</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> <dc:date rdf:datatype="">2011-03-24T17:34:29Z</dc:date> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:isPartOf rdf:resource=""/> <dc:contributor>Begemann, Gerrit</dc:contributor> </rdf:Description> </rdf:RDF>

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