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Autophagic tubes : vacuolar invaginations involved inlateral membrane sorting and inverse vesicle budding

Autophagic tubes : vacuolar invaginations involved inlateral membrane sorting and inverse vesicle budding

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MÜLLER, Oliver, Tanja SATTLER, Matthias FLÖTENMEYER, Heinz SCHWARZ, Helmut PLATTNER, Andreas MAYER, 2000. Autophagic tubes : vacuolar invaginations involved inlateral membrane sorting and inverse vesicle budding. In: Journal of Cell Biology. 151, pp. 519-528

@article{Muller2000Autop-7431, title={Autophagic tubes : vacuolar invaginations involved inlateral membrane sorting and inverse vesicle budding}, year={2000}, volume={151}, journal={Journal of Cell Biology}, pages={519--528}, author={Müller, Oliver and Sattler, Tanja and Flötenmeyer, Matthias and Schwarz, Heinz and Plattner, Helmut and Mayer, Andreas} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7431"> <dc:creator>Flötenmeyer, Matthias</dc:creator> <dc:contributor>Plattner, Helmut</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:34:23Z</dc:date> <dcterms:title>Autophagic tubes : vacuolar invaginations involved inlateral membrane sorting and inverse vesicle budding</dcterms:title> <dc:contributor>Flötenmeyer, Matthias</dc:contributor> <dc:creator>Plattner, Helmut</dc:creator> <dcterms:bibliographicCitation>First publ. in: Journal of Cell Biology 151 (2000), pp. 519-528</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:creator>Müller, Oliver</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7431"/> <dc:format>application/pdf</dc:format> <dc:creator>Schwarz, Heinz</dc:creator> <dc:rights>deposit-license</dc:rights> <dcterms:abstract xml:lang="eng">Many intracellular compartments of eukaryotic cells do not adopt a spherical shape, which would be expected in the absence of mechanisms organizing their structure. However, little is known about the principles determining the shape of organelles. We have observed very defined structural changes of vacuoles, the lysosome equivalents of yeast. The vacuolar membrane can form a large tubular invagination from which vesicles bud off into the lumen of the organelle. Formation of the tube is regulated via the Apg/Aut pathway. Its lumen is continuous with the cytosol, making this inverse budding reaction equivalent to microautophagocytosis. The tube is highly dynamic, often branched, and defined by a sharp kink of the vacuolar membrane at the site of invagination. The tube is formed by vacuoles in an autonomous fashion. It persists after vacuole isolation and, therefore, is independent of surrounding cytoskeleton. There is a striking lateral heterogeneity along the tube, with a high density of transmembrane particles at the base and a smooth zone devoid of transmembrane particles at the tip where budding occurs. We postulate a lateral sorting mechanism along the tube that mediates a depletion of large transmembrane proteins at the tip and results in the inverse budding of lipid-rich vesicles into the lumen of the organelle.</dcterms:abstract> <dc:contributor>Mayer, Andreas</dc:contributor> <dc:creator>Mayer, Andreas</dc:creator> <dc:language>deu</dc:language> <dc:creator>Sattler, Tanja</dc:creator> <dc:contributor>Schwarz, Heinz</dc:contributor> <dc:contributor>Müller, Oliver</dc:contributor> <dc:contributor>Sattler, Tanja</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:34:23Z</dcterms:available> <dcterms:issued>2000</dcterms:issued> </rdf:Description> </rdf:RDF>

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