KOPS - Das Institutionelle Repositorium der Universität Konstanz

A Command Chemical Triggers an Innate Behavior by Sequential Activation of Multiple Peptidergic Ensembles

A Command Chemical Triggers an Innate Behavior by Sequential Activation of Multiple Peptidergic Ensembles

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:ff309170ba9e755b78f50d7de5b2358f

KIM, Young-Joon, Du an ITNAN, Cosmas Giovanni GALIZIA, Kook-Ho CHO, Michael E. ADAMS, 2006. A Command Chemical Triggers an Innate Behavior by Sequential Activation of Multiple Peptidergic Ensembles. In: Current Biology. 16(14), pp. 1395-1407. ISSN 0960-9822

@article{Kim2006Comma-7390, title={A Command Chemical Triggers an Innate Behavior by Sequential Activation of Multiple Peptidergic Ensembles}, year={2006}, doi={10.1016/j.cub.2006.06.027}, number={14}, volume={16}, issn={0960-9822}, journal={Current Biology}, pages={1395--1407}, author={Kim, Young-Joon and itnan, Du an and Galizia, Cosmas Giovanni and Cho, Kook-Ho and Adams, Michael E.} }

deposit-license First publ. in: Current Biology 16 (2006), 14, pp. 1395-1407 Background: At the end of each molt, insects shed their old cuticle by performing the ecdysis sequence, an innate behavior consisting of three steps: pre-ecdysis, ecdysis, and postecdysis. Blood-borne ecdysis-triggering hormone (ETH) activates the behavioral sequence through direct actions on the central nervous system.<br />Results: To elucidate neural substrates underlying the ecdysis sequence, we identified neurons expressing ETH receptors (ETHRs) in Drosophila. Distinct ensembles of ETHR neurons express numerous neuropeptides including kinin, FMRFamides, eclosion hormone (EH), crustacean cardioactive peptide (CCAP), myoinhibitory peptides (MIP), and bursicon. Real-time imaging of intracellular calcium dynamics revealed sequential activation of these ensembles after ETH action. Specifically, FMRFamide neurons are activated during pre-ecdysis; EH, CCAP, and CCAP/MIP neurons are active prior to and during ecdysis; and activity of CCAP/MIP/bursicon neurons coincides with postecdysis. Targeted ablation of specific ETHR ensembles produces behavioral deficits consistent with their proposed roles in the behavioral sequence.<br />Conclusions: Our findings offer novel insights into how a command chemical orchestrates an innate behavior by stepwise recruitment of central eptidergic ensembles. A Command Chemical Triggers an Innate Behavior by Sequential Activation of Multiple Peptidergic Ensembles Galizia, Cosmas Giovanni Kim, Young-Joon eng 2006 Kim, Young-Joon Cho, Kook-Ho Adams, Michael E. itnan, Du an 2011-03-24T17:34:03Z Cho, Kook-Ho Adams, Michael E. itnan, Du an 2011-03-24T17:34:03Z Galizia, Cosmas Giovanni application/pdf

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

Kim06_CurrBiol.pdf 189

Das Dokument erscheint in:

KOPS Suche


Stöbern

Mein Benutzerkonto