Substantial reduction of naïve and regulatory T cells following traumatic stress

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SOMMERSHOF, Annette, Hannah AICHINGER, Harald ENGLER, Hannah ADENAUER, Claudia CATANI, Eva-Maria BONEBERG, Thomas ELBERT, Marcus GROETTRUP, Iris-Tatjana KOLASSA, 2009. Substantial reduction of naïve and regulatory T cells following traumatic stress. In: Brain, Behavior, and Immunity. 23(8), pp. 1117-1124. ISSN 0889-1591. eISSN 1090-2139

@article{Sommershof2009Subst-7292, title={Substantial reduction of naïve and regulatory T cells following traumatic stress}, year={2009}, number={8}, volume={23}, issn={0889-1591}, journal={Brain, Behavior, and Immunity}, pages={1117--1124}, author={Sommershof, Annette and Aichinger, Hannah and Engler, Harald and Adenauer, Hannah and Catani, Claudia and Boneberg, Eva-Maria and Elbert, Thomas and Groettrup, Marcus and Kolassa, Iris-Tatjana} }

Sommershof, Annette Boneberg, Eva-Maria Catani, Claudia application/pdf Groettrup, Marcus eng Elbert, Thomas deposit-license Engler, Harald Catani, Claudia Boneberg, Eva-Maria Engler, Harald Kolassa, Iris-Tatjana Sommershof, Annette First publ. in: Brain, Behavior, and Immunity ; 23 (2009), 8. - S. 1117-1124 Substantial reduction of naïve and regulatory T cells following traumatic stress 2009 2011-03-24T17:33:17Z Elbert, Thomas Aichinger, Hannah Groettrup, Marcus Adenauer, Hannah Posttraumatic stress disorder (PTSD) is associated with an enhanced susceptibility to various somatic diseases. However, the exact mechanisms linking traumatic stress to subsequent physical health problems have remained unclear. This study investigated peripheral T lymphocyte differentiation subsets in 19 individuals with war and torture related PTSD compared to 27 non-PTSD controls (n = 14 traumaexposed controls; n = 13 non-exposed controls). Peripheral T cell subpopulations were classified by their characteristic expression of the lineage markers CD45RA and CCR7 into: naïve (CD45RA+ CCR7+), central memory (TCM: CD45RA- CCR7+) and effector memory (TEM: CD45RA- CCR7- and TEMRA: CD45RA- CCR7-) cells. Furthermore, we analyzed regulatory T cells (CD4+CD25+FoxP3+) and ex vivo proliferation responses of peripheral blood mononuclear cells after stimulation with anti-CD3 monoclonal antibody. Results show that the proportion of naïve CD8+ T lymphocytes was reduced by 32% (p = 0.01), whereas the proportions of CD3+ central (p = 0.02) and effector (p = 0.01) memory T lymphocytes were significantly enhanced (+22% and +34%, respectively) in PTSD patients compared to non-PTSD individuals. To a smaller extent, this effect was also observed in trauma-exposed non-PTSD individuals, indicating a cumulative effect of traumatic stress on T cell distribution. Moreover, PTSD patients displayed a 48% reduction in the proportion of regulatory T cells (p < 0.001). Functionally, these alterations were accompanied by a significantly enhanced (+34%) ex vivo proliferation of anti-CD3 stimulated T cells (p = 0.05). The profoundly altered composition of the peripheral T cell compartment might cause a state of compromised immune responsiveness, which may explain why PTSD patients show an increased susceptibility to infections, and inflammatory and autoimmune diseases. Adenauer, Hannah Kolassa, Iris-Tatjana Aichinger, Hannah

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