Heterozygous Toll-Like Receptor 2 Polymorphism Does Not Affect Lipoteichoic Acid-Induced Chemokine and Inflammatory Responses

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2004
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Schröder, Nicolas W. J.
Traub, Stephanie
Gueinzius, Katja
Lorenz, Eva
Schumann, Ralf R.
Hermann, Corinna
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Infection and Immunity ; 72 (2004), 3. - pp. 1828-1831. - ISSN 0019-9567
Abstract
While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.
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570 Biosciences, Biology
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ISO 690AULOCK, Sonja von, Nicolas W. J. SCHRÖDER, Stephanie TRAUB, Katja GUEINZIUS, Eva LORENZ, Thomas HARTUNG, Ralf R. SCHUMANN, Corinna HERMANN, 2004. Heterozygous Toll-Like Receptor 2 Polymorphism Does Not Affect Lipoteichoic Acid-Induced Chemokine and Inflammatory Responses. In: Infection and Immunity. 72(3), pp. 1828-1831. ISSN 0019-9567. Available under: doi: 10.1128/IAI.72.3.1828-1831.2004
BibTex
@article{Aulock2004Heter-7235,
  year={2004},
  doi={10.1128/IAI.72.3.1828-1831.2004},
  title={Heterozygous Toll-Like Receptor 2 Polymorphism Does Not Affect Lipoteichoic Acid-Induced Chemokine and Inflammatory Responses},
  number={3},
  volume={72},
  issn={0019-9567},
  journal={Infection and Immunity},
  pages={1828--1831},
  author={Aulock, Sonja von and Schröder, Nicolas W. J. and Traub, Stephanie and Gueinzius, Katja and Lorenz, Eva and Hartung, Thomas and Schumann, Ralf R. and Hermann, Corinna}
}
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    <dcterms:abstract xml:lang="eng">While transfection of tlr2 conveyed responsiveness to lipoteichoic acid (LTA), the Arg753Gln polymorphic gene could not. LTA induced a stronger chemokine and anti-inflammatory response than lipopolysaccharides did. Blood from heterozygous polymorphic and wild-type donors reacted uniformly to LTA and Staphylococcus aureus. Thus, one functional allele for Toll-like receptor 2 suffices for full cytokine response.</dcterms:abstract>
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