Identification and structure of a novel flavin prosthetic group associated with reduced nicotinamide adenine dinucleotide dehydrogenase from Peptostreptococcus elsdenii
| Publikationstyp: | Zeitschriftenartikel |
| URI (zitierfähiger Link): | http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-55267 |
| Autor/innen: | Ghisla, Sandro; Mayhew, Stephen G. |
| Erscheinungsjahr: | 1973 |
| Erschienen in: | Journal of Biological Chemistry ; 248 (1973), 18. - S. 6568-6570 |
| Zusammenfassung: |
A novel prosthetic group, which is present in NADH dehydrogenase (EC 1.6.99.3) from Pepfosfrejfococcus etsdenii, has been purified and its physicochemical properties investigated. The chemical structure of this species has been established as the FAD analogue of 7-methyl-8-hydroxyisoalloxazine. The proposed structure is confirmed by: (a) chemical synthesis of 7-methyl-8-hydroxy-isoahoxazine models and comparison of their spectral and physical properties with those of the natural chromophore, and (b) photochemical degradation of the N(lO)-polyhydroxy side chain of the FMN portion of the isolated coenzyme to yield 7-methyl-8-hydroxy-alloxazine. The synthesis of these models is outlined.
|
| Fachgebiet (DDC): | 570 Biowissenschaften, Biologie |
| Link zur Lizenz: | Nutzungsbedingungen |
Zitieren
Dateien zu dieser Ressource
![[PDF]](/themes/Kops/images/mimes/pdf.png "PDF file"){kind=small}
GHISLA, Sandro, Stephen G. MAYHEW, 1973. Identification and structure of a novel flavin prosthetic group associated with reduced nicotinamide adenine dinucleotide dehydrogenase from Peptostreptococcus elsdenii. In: Journal of Biological Chemistry. 248(18), pp. 6568-6570
@article{Ghisla1973Ident-7193, title={Identification and structure of a novel flavin prosthetic group associated with reduced nicotinamide adenine dinucleotide dehydrogenase from Peptostreptococcus elsdenii}, year={1973}, number={18}, volume={248}, journal={Journal of Biological Chemistry}, pages={6568--6570}, author={Ghisla, Sandro and Mayhew, Stephen G.} }
<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7193"> <dc:language>eng</dc:language> <dc:contributor>Ghisla, Sandro</dc:contributor> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7193"/> <dc:contributor>Mayhew, Stephen G.</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Journal of Biological Chemistry 248 (1973), 18, pp. 6568-6570</dcterms:bibliographicCitation> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:rights>terms-of-use</dc:rights> <dcterms:abstract xml:lang="deu">A novel prosthetic group, which is present in NADH dehydrogenase (EC 1.6.99.3) from Pepfosfrejfococcus etsdenii, has been purified and its physicochemical properties investigated. The chemical structure of this species has been established as the FAD analogue of 7-methyl-8-hydroxyisoalloxazine. The proposed structure is confirmed by: (a) chemical synthesis of 7-methyl-8-hydroxy-isoahoxazine models and comparison of their spectral and physical properties with those of the natural chromophore, and (b) photochemical degradation of the N(lO)-polyhydroxy side chain of the FMN portion of the isolated coenzyme to yield 7-methyl-8-hydroxy-alloxazine. The synthesis of these models is outlined.</dcterms:abstract> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7193/1/Identification_and_Structure_of_a_Novel_Flavin_Prosthetic_Group_Associated.pdf"/> <dc:creator>Ghisla, Sandro</dc:creator> <dcterms:issued>1973</dcterms:issued> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:32Z</dcterms:available> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/7193/1/Identification_and_Structure_of_a_Novel_Flavin_Prosthetic_Group_Associated.pdf"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:32Z</dc:date> <dc:creator>Mayhew, Stephen G.</dc:creator> <dcterms:title>Identification and structure of a novel flavin prosthetic group associated with reduced nicotinamide adenine dinucleotide dehydrogenase from Peptostreptococcus elsdenii</dcterms:title> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:format>application/pdf</dc:format> </rdf:Description> </rdf:RDF>
Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)
| Identification_and_Structure_of_a_Novel_Flavin_Prosthetic_Group_Associated.pdf | 97 |
Das Dokument erscheint in:
Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: terms-of-use
KOPS Suche
Stöbern
Mein Benutzerkonto
