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The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function

The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function

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FALSIG, Jeppe, Peter PÖRZGEN, Søren LUND, André SCHRATTENHOLZ, Marcel LEIST, 2006. The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function. In: Journal of Neurochemistry. 96(3), pp. 893-907. ISSN 0022-3042. eISSN 1471-4159

@article{Falsig2006infla-7174, title={The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function}, year={2006}, doi={10.1111/j.1471-4159.2005.03622.x}, number={3}, volume={96}, issn={0022-3042}, journal={Journal of Neurochemistry}, pages={893--907}, author={Falsig, Jeppe and Pörzgen, Peter and Lund, Søren and Schrattenholz, André and Leist, Marcel} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7174"> <dc:creator>Schrattenholz, André</dc:creator> <dc:format>application/pdf</dc:format> <dc:contributor>Falsig, Jeppe</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:creator>Lund, Søren</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:25Z</dcterms:available> <dc:contributor>Lund, Søren</dc:contributor> <dc:contributor>Schrattenholz, André</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:25Z</dc:date> <dcterms:abstract xml:lang="eng">Upon injury, astrocytes assume an activated state associated with the release of inflammatory mediators. To model this, we stimulated murine primary astrocytes with a complete inflammatory cytokine mix consisting of TNF-α, IL-1β and IFN-γ. We analysed the transcriptional response of 480 genes at 4 and 16 h after stimulation on a chip designed to give a representative overview over the inflammation-relevant part of the transcriptome of macrophage-like cells. The list of the 182 genes found to be significantly regulated in astrocytes revealed an intriguing co-ordinate regulation of genes linked to the biological processes of antiviral/antimicrobial defence, antigen presentation and facilitation of leucocyte invasion. The latter group was characterized by very high up-regulations of chemokine genes. We also identified regulations of a thymidylate kinase and an interferon-regulated protein with a tetratricopeptide motive, both up to now only known from macrophages. The transcriptional regulations were confirmed on the protein level by a proteomic analysis. These findings taken together suggest that activated astrocytes in brain behave similarly in many respects to inflamed macrophages in the periphery.</dcterms:abstract> <dc:creator>Leist, Marcel</dc:creator> <dcterms:bibliographicCitation>First publ. in: Journal of Neurochemistry 96 (2006), 3, pp. 893-907</dcterms:bibliographicCitation> <dc:contributor>Pörzgen, Peter</dc:contributor> <dc:language>eng</dc:language> <dcterms:issued>2006</dcterms:issued> <dc:creator>Pörzgen, Peter</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7174"/> <dc:contributor>Leist, Marcel</dc:contributor> <dcterms:title>The inflammatory transcriptome of reactive murine astrocytes and implications for their innate immune function</dcterms:title> <dc:creator>Falsig, Jeppe</dc:creator> </rdf:Description> </rdf:RDF>

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