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A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption

A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption

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Prüfsumme: MD5:44532194098c8ff8bc7356378a3cfa6b

MÜLLER, Georg Johannes, Marie Aavang GEIST, Lone Merete VENG, Mette Georgi WILLESEN, Flemming Fryd JOHANSEN, Marcel LEIST, Elisabetta VAUDANO, 2006. A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption. In: Journal of Neurochemistry. 96(5), pp. 1242-1252. ISSN 0022-3042. eISSN 1471-4159

@article{Muller2006mixed-7149, title={A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption}, year={2006}, number={5}, volume={96}, issn={0022-3042}, journal={Journal of Neurochemistry}, pages={1242--1252}, author={Müller, Georg Johannes and Geist, Marie Aavang and Veng, Lone Merete and Willesen, Mette Georgi and Johansen, Flemming Fryd and Leist, Marcel and Vaudano, Elisabetta} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7149"> <dc:contributor>Geist, Marie Aavang</dc:contributor> <dcterms:issued>2006</dcterms:issued> <dcterms:title>A role for mixed lineage kinases in granule cell apoptosis induced by cytoskeletal disruption</dcterms:title> <dc:creator>Willesen, Mette Georgi</dc:creator> <dc:creator>Johansen, Flemming Fryd</dc:creator> <dcterms:bibliographicCitation>First publ. in: Journal of Neurochemistry 96 (2006), 5, pp. 1242-1252</dcterms:bibliographicCitation> <dc:contributor>Vaudano, Elisabetta</dc:contributor> <dc:creator>Veng, Lone Merete</dc:creator> <dc:contributor>Müller, Georg Johannes</dc:contributor> <dc:contributor>Johansen, Flemming Fryd</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:14Z</dcterms:available> <dc:rights>deposit-license</dc:rights> <dc:contributor>Willesen, Mette Georgi</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:32:14Z</dc:date> <dcterms:abstract xml:lang="eng">Microtubule disruption by colchicine induces apoptosis in selected neuronal populations. However, little is known about the upstream death signalling events mediating the neurotoxicity. We investigated first whether colchicine-induced granule cell apoptosis activates the c-Jun N-terminal kinase (JNK) pathway. Cultured murine cerebellar granule cells were exposed to 1 lM colchicine for 24 h. Activation of the JNK pathway was detected by western blotting as well as immunocytochemistry using antibodies against phosphoc- Jun (p-c-Jun). Next, adult male rats were injected intracerebroventricularly with colchicine (10 lg), and JNK pathway activation in dentate granule cells (DGCs) was detected by antibodies against p-c-Jun. The second part of the study tested the involvement of mixed lineage kinases (MLK) as upstream activators of the JNK pathway in colchicine toxicity, using CEP-1347, a potent MLK inhibitor. In vitro, significant inhibition of the JNK pathway, activated by colchicine, was achieved by 100 300 nM CEP-1347, which blocked both activation of cell death proteases and apoptosis. Moreover, CEP-1347 markedly delayed neurite fragmentation and cell degeneration. In vivo, CEP-1347 (1 mg/kg) significantly prevented p-c-jun increase following injection of colchicine, and enhanced survival of DGCs. We conclude that colchicineinduced neuronal apoptosis involves the JNK/MLK pathway, and that protection of granule cells can be achieved by MLK inhibition.</dcterms:abstract> <dc:contributor>Leist, Marcel</dc:contributor> <dc:creator>Vaudano, Elisabetta</dc:creator> <dc:creator>Leist, Marcel</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7149"/> <dc:creator>Müller, Georg Johannes</dc:creator> <dc:language>eng</dc:language> <dc:contributor>Veng, Lone Merete</dc:contributor> <dc:creator>Geist, Marie Aavang</dc:creator> <dc:format>application/pdf</dc:format> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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