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Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na,K-pump

Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na,K-pump

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APELL, Hans-Jürgen, M. NELSON, Madeleine M. MARCUS, Peter LÄUGER, 1986. Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na,K-pump. In: Biochimica et Biophysica Acta - Biomembranes. 857(1), pp. 105-115. ISSN 0005-2736

@article{Apell1986Effec-7113, title={Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na,K-pump}, year={1986}, doi={10.1016/0005-2736(86)90103-3}, number={1}, volume={857}, issn={0005-2736}, journal={Biochimica et Biophysica Acta - Biomembranes}, pages={105--115}, author={Apell, Hans-Jürgen and Nelson, M. and Marcus, Madeleine M. and Läuger, Peter} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7113"> <dc:contributor>Marcus, Madeleine M.</dc:contributor> <dcterms:issued>1986</dcterms:issued> <dc:creator>Marcus, Madeleine M.</dc:creator> <dc:contributor>Apell, Hans-Jürgen</dc:contributor> <dc:contributor>Nelson, M.</dc:contributor> <dc:contributor>Läuger, Peter</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:34Z</dc:date> <dcterms:bibliographicCitation>First publ. in: Biochimica et Biophysica Acta - Biomembranes 857 (1986), 105-115</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:rights>deposit-license</dc:rights> <dcterms:title>Effects of the ATP, ADP and inorganic phosphate on the transport rate of the Na,K-pump</dcterms:title> <dc:creator>Nelson, M.</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:34Z</dcterms:available> <dc:creator>Apell, Hans-Jürgen</dc:creator> <dc:format>application/pdf</dc:format> <dcterms:abstract xml:lang="eng">(Na+K)-ATPase from kidney outer medulla was incorporated into artificial dioleoylphosphatidylcholine vesicles. In the reconstituted system the pump can be activated by adding ATP to the external medium. ATP-driven potassium extrusion by the Na,K-pump was studied using a voltage-sensitive dye in the presence of valinomycin. ADP strongly reduced the turnover rate of the pump with a concentration for half-maximal inhibition of cD,1/2 =0.1 mM. cD,1/2 was found to be virtually independent of ATP concentration, indicating that the inhibition is non-competitive with respect to ATP. The non-competitive inhibition by ADP can be explained on the basis of the Post-Albers reaction cycle of the Na,K-pump, assuming that the main action of ADP is the reversal of the phosphorylation step.</dcterms:abstract> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7113"/> <dc:creator>Läuger, Peter</dc:creator> </rdf:Description> </rdf:RDF>

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