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Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens

Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens

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Prüfsumme: MD5:8b1a3c6f54206d8f563614d0dfd3c30e

KARAMITOPOULOU, Eva, Cyrill A. RENTSCH, Regula MARKWALDER, Claudio VALLAN, George N. THALMANN, Thomas BRUNNER, 2010. Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens. In: Pathology. 42(1), pp. 37-42. ISSN 0031-3025. eISSN 1465-3931

@article{Karamitopoulou2010Progn-7086, title={Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens}, year={2010}, doi={10.3109/00313020903434397}, number={1}, volume={42}, issn={0031-3025}, journal={Pathology}, pages={37--42}, author={Karamitopoulou, Eva and Rentsch, Cyrill A. and Markwalder, Regula and Vallan, Claudio and Thalmann, George N. and Brunner, Thomas} }

Rentsch, Cyrill A. eng Markwalder, Regula Karamitopoulou, Eva deposit-license Brunner, Thomas Thalmann, George N. Vallan, Claudio Vallan, Claudio 2010 First publ. in: Pathology 42 (2010), 1, pp. 37-42 Brunner, Thomas application/pdf 2012-07-31T22:25:04Z 2011-03-24T17:31:24Z Markwalder, Regula Karamitopoulou, Eva Aims: To assess the prognostic significance of apoptosis related markers in bladder cancer.<br />Methods: A tissue microarray containing 179 bladder carcinomas from cystectomy specimens was analysed immunohistochemically for active caspase-3, single-stranded DNA (ssDNA), p53, Bcl-2, Bax, and COX-2, in correlation to clinicopathological factors.<br />Results: Active caspase-3, ssDNA, p53, Bax and COX-2 were more frequently observed among high grade and higher stage (!T2) carcinomas compared with low grade and lower stage (T1) tumours. On the contrary, Bcl-2 was more frequently detected in T1 than in !T2 carcinomas. Active caspase-3 correlated with a better survival of the patients.<br />Conclusions: The decreased detection of active caspase-3 and ssDNA and the increased presence of Bcl-2 in T1 carcinomas suggest that alterations in interrelated apoptosis markers may play an important role in the progression of urothelial carcinoma from a superficially infiltrating to a muscle invading tumour and would help to better characterise a subpopulation of T1 carcinomas that could profit from early cystectomy or more aggressive adjuvant chemotherapy. Active caspase-3 might be an important prognostic factor in bladder cancer. Prognostic significance of apoptotic cell death in bladder cancer : a tissue microarray study on 179 urothelial carcinomas from cystectomy specimens Thalmann, George N. Rentsch, Cyrill A.

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