KOPS - Das Institutionelle Repositorium der Universität Konstanz

A reticular rhapsody : phylogenic evolution and nomenclature of the RTN/Nogo gene family

A reticular rhapsody : phylogenic evolution and nomenclature of the RTN/Nogo gene family

Zitieren

Dateien zu dieser Ressource

Prüfsumme: MD5:76d072bea83055b5dfcda0d45be4f9bc

OERTLE, Thomas, Michael KLINGER, Claudia STÜRMER, Martin E. SCHWAB, 2003. A reticular rhapsody : phylogenic evolution and nomenclature of the RTN/Nogo gene family. In: FASEB Journal. 17(10), pp. 1238-1247. ISSN 0892-6638. eISSN 1530-6860

@article{Oertle2003retic-7057, title={A reticular rhapsody : phylogenic evolution and nomenclature of the RTN/Nogo gene family}, year={2003}, doi={10.1096/fj.02-1166hyp}, number={10}, volume={17}, issn={0892-6638}, journal={FASEB Journal}, pages={1238--1247}, author={Oertle, Thomas and Klinger, Michael and Stürmer, Claudia and Schwab, Martin E.} }

2011-03-24T17:31:10Z Stürmer, Claudia Klinger, Michael Klinger, Michael 2003 Oertle, Thomas application/pdf Stürmer, Claudia eng Reticulon (RTN) genes code for a family of proteins relatively recently described in higher vertebrates. The four known mammalian paralogues<br />(RTN1, -2, -3, and -4/Nogo) have homologous carboxyl termini with two characteristic large hydrophobic regions. Except for RTN4-A/Nogo-A, thought to be an inhibitor for neurite outgrowth, restricting the regenerative capabilities of the mammalian CNS after injury, the functions of other family members are largely unknown. The overall occurrence of RTNs in different phyla and the evolution of the RTN gene family have hitherto not been analyzed. Here we expound data showing that the RTN family has arisen during early eukaryotic evolution potentially concerted to the establishment of the endomembrane system. Over 250 reticulon-like (RTNL) genes were identified in deeply diverging eukaryotes, fungi, plants, and animals. A systematic nomenclature for all identified family members is introduced. The analysis of exon-intron arrangements and of protein homologies allowed us to isolate key steps in the history of these genes. Our data corroborate the hypothesis that present RTNs evolved from an intron-rich reticulon ancestor mainly by the loss of different introns in diverse phyla. We also present evidence that the exceptionally large RTN4-Aspecific exon 3, which harbors a potent neurite growth inhibitory region, may have arisen de novo -350 MYA during transition to land vertebrates. These data emphasize on the one hand the universal role of reticulons in the eukaryotic system and on the other hand the acquisition of putative new functions through acquirement of novel amino-terminal exons. 2011-03-24T17:31:10Z First publ. in: FASEB Journal 17 (2003), 10, pp. 1238-1247 A reticular rhapsody : phylogenic evolution and nomenclature of the RTN/Nogo gene family Oertle, Thomas deposit-license Schwab, Martin E. Schwab, Martin E.

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

101_Phylogenetic_evolution_and_nomenclature.pdf 508

Das Dokument erscheint in:

deposit-license Solange nicht anders angezeigt, wird die Lizenz wie folgt beschrieben: deposit-license

KOPS Suche


Stöbern

Mein Benutzerkonto