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Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide

Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide

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BOHLINGER, Ines, Marcel LEIST, Johannes BARSIG, Stefan UHLIG, Gisa TIEGS, Albrecht WENDEL, 1995. Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide. In: Toxicology Letters. 82/83, pp. 227-231. ISSN 0378-4274

@article{Bohlinger1995Toler-7047, title={Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide}, year={1995}, doi={10.1016/0378-4274(95)03480-3}, volume={82/83}, issn={0378-4274}, journal={Toxicology Letters}, pages={227--231}, author={Bohlinger, Ines and Leist, Marcel and Barsig, Johannes and Uhlig, Stefan and Tiegs, Gisa and Wendel, Albrecht} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/7047"> <dcterms:issued>1995</dcterms:issued> <dcterms:title>Tolerance against tumor necrosis factor alpha (TNF)-induced hepatotoxicity in mice : the role of nitric oxide</dcterms:title> <dc:rights>deposit-license</dc:rights> <dc:contributor>Bohlinger, Ines</dc:contributor> <dc:creator>Tiegs, Gisa</dc:creator> <dc:contributor>Tiegs, Gisa</dc:contributor> <dc:creator>Leist, Marcel</dc:creator> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:contributor>Leist, Marcel</dc:contributor> <dc:contributor>Barsig, Johannes</dc:contributor> <dc:contributor>Uhlig, Stefan</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:06Z</dc:date> <dc:contributor>Wendel, Albrecht</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/7047"/> <dcterms:abstract xml:lang="eng">D-Galactosamine-sensitized mice challenged with tumor necrosis factor α (TNF) developed severe apoptotic and secondary necrotic liver injury as assessed by histology, measurement of cytosolic DNA fragments and determination of liver-specific enzymes in plasma. Pretreatment of mice with interleukin-1β (IL-1) resulted in elevated levels of nitrite/nitrate in serum and rendered mice insensitive towards TNF toxicity. Pharmacological doses of the nitric oxide (NO) donor sodium nitroprusside (SNP) also conferred complete protection against TNF toxicity, suggesting a possible link between IL-1- and NO-induced protection. However, NO-synthesis inhibition by NG-monomethyl-L-arginine failed to abrogate IL-1-induced tolerance against TNF toxicity. We conclude that IL-1 and NO protect against TNF-induced liver injury through distinct pathways.</dcterms:abstract> <dc:creator>Uhlig, Stefan</dc:creator> <dc:language>eng</dc:language> <dc:format>application/pdf</dc:format> <dc:creator>Wendel, Albrecht</dc:creator> <dcterms:bibliographicCitation>First publ. in: Toxicology Letters 82/83 (1995), pp. 227-231</dcterms:bibliographicCitation> <dc:creator>Barsig, Johannes</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:31:06Z</dcterms:available> <dc:creator>Bohlinger, Ines</dc:creator> </rdf:Description> </rdf:RDF>

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