Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility

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Datum
2024
Autor:innen
Pamies, David
Ekert, Jason
Zurich, Marie-Gabrielle
Frey, Olivier
Werner, Sophie
Piergiovanni, Monica
Freedman, Benjamin S.
Keong Teo, Adrian Kee
et al.
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http://nbn-resolving.de/urn:nbn:de:bsz:352-2-13t1p8cyy0jgb8
DOI (zitierfähiger Link)
https://doi.org/10.1016/j.stemcr.2024.03.009
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CC BY 4.0

Angaben zur Forschungsförderung
European Union (EU): 964537
European Union (EU): 964518
European Union (EU): 101057014
Institutionen der Bundesrepublik Deutschland: INVITE2
Projekt
RISK-HUNT3R
PARC: Partnership for the Assessment of Risks from Chemicals
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Open Access Gold
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Biologie
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Published
Erschienen in
Stem Cell Reports. Elsevier. 2024, 19(5), S. 604-617. eISSN 2213-6711. Verfügbar unter: doi: 10.1016/j.stemcr.2024.03.009
Zusammenfassung

Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting. These advancements, termed microphysiological systems (MPSs), closely replicate tissue environments and human physiology, enhancing research and biomedical uses. However, MPS complexity introduces standardization challenges, impacting reproducibility and trust. We offer guidelines for quality management and control criteria specific to MPSs, facilitating reliable outcomes without stifling innovation. Our fit-for-purpose recommendations provide actionable advice for achieving consistent MPS performance.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
Schlagwörter
microphysiological systems, organoids, organ on chip, spheroids, reproducibility, quality control, standards, criteria, recommendations, in vitro
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ISO 690PAMIES, David, Jason EKERT, Marie-Gabrielle ZURICH, Olivier FREY, Sophie WERNER, Monica PIERGIOVANNI, Benjamin S. FREEDMAN, Adrian Kee KEONG TEO, Thomas HARTUNG, Marcel LEIST, 2024. Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility. In: Stem Cell Reports. Elsevier. 2024, 19(5), S. 604-617. eISSN 2213-6711. Verfügbar unter: doi: 10.1016/j.stemcr.2024.03.009
BibTex
@article{Pamies2024-05Recom-69980,
  year={2024},
  doi={10.1016/j.stemcr.2024.03.009},
  title={Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility},
  number={5},
  volume={19},
  journal={Stem Cell Reports},
  pages={604--617},
  author={Pamies, David and Ekert, Jason and Zurich, Marie-Gabrielle and Frey, Olivier and Werner, Sophie and Piergiovanni, Monica and Freedman, Benjamin S. and Keong Teo, Adrian Kee and Hartung, Thomas and Leist, Marcel}
}
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