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Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans

Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans

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STUDER-ROHR, Irène, Josef SCHLATTER, Daniel R. DIETRICH, 2000. Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans. In: Archives of Toxicology. 74(9), pp. 499-510. ISSN 0340-5761. eISSN 1432-0738

@article{StuderRohr2000Kinet-6966, title={Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans}, year={2000}, number={9}, volume={74}, issn={0340-5761}, journal={Archives of Toxicology}, pages={499--510}, author={Studer-Rohr, Irène and Schlatter, Josef and Dietrich, Daniel R.} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/6966"> <dcterms:issued>2000</dcterms:issued> <dc:language>eng</dc:language> <dc:contributor>Dietrich, Daniel R.</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6966"/> <dcterms:bibliographicCitation>First publ. in: Archives of Toxicology 74 (2000), 9, pp. 499-510</dcterms:bibliographicCitation> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Studer-Rohr, Irène</dc:contributor> <dc:creator>Studer-Rohr, Irène</dc:creator> <dc:creator>Schlatter, Josef</dc:creator> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/6966/1/Kinetic_parameters_and_intraindividual_fluctuations_of_ochratoxin_A_plasma_levels_in_humans.pdf"/> <dc:contributor>Schlatter, Josef</dc:contributor> <dc:format>application/pdf</dc:format> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:rights>terms-of-use</dc:rights> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:30:29Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:30:29Z</dcterms:available> <dcterms:abstract xml:lang="eng">The mycotoxin ochratoxin A (OTA) is a rodent carcinogen produced by species of the ubiquitous fungal genera Aspergillus and Penicillium. OTA is found in a variety of food items and as a consequence is also found in human plasma (average concentrations found in this study: 0.1-1 ng OTA/ml plasma). To improve the scientific basis for cancer risk assessment the toxicokinetic profile of OTA was studied in one human volunteer following ingestion of 395 ng [3]H-labeled OTA (3.8 μCi). A two-compartment open model consisting of a central compartment was found to best describe the in vivo data. This two-compartment model consisted of a fast elimination and distribution phase (T[1/2] about 20 h) followed by a slow elimination phase (renal clearance about 0.11 ml/min.) and a calculated plasma half-life of 35.55 days. This half-life was approximately eight times longer than that determined previously in rats. In addition, the intraindividual fluctuation of OTA plasma levels was investigated in eight individuals over a period of 2 months. The concentrations determined ranged between 0.2 and 0.9 ng OTA/ml plasma. The plasma levels in some individuals remained nearly constant over time, while others varied considerably (e.g. increase of 0.4 ng/ml within 3 days, decrease of 0.3 ng/ml within 5 days) during the observation period. This intraindividual fluctuation in OTA plasma levels, which may represent differences in OTA exposure and/or metabolism, as well as the large difference in plasma half-life in humans compared to rats must be taken into consideration when the results of rat cancer study data are extrapolated to humans for risk assessment purposes.</dcterms:abstract> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Dietrich, Daniel R.</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:title>Kinetic parameters and intraindividual fluctuations of ochratoxin A plasma levels in humans</dcterms:title> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/6966/1/Kinetic_parameters_and_intraindividual_fluctuations_of_ochratoxin_A_plasma_levels_in_humans.pdf"/> </rdf:Description> </rdf:RDF>

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