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Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion

Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion

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NYLANDSTED, Jesper, Wolfgang WICK, Ulrich HIRT, Karsten BRAND, Mikkel ROHDE, Marcel LEIST, Michael WELLER, Marja JÄÄTTELÄ, 2002. Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion. In: Cancer Research. 62(24), pp. 7139-7142. ISSN 0008-5472. eISSN 1538-7445

@article{Nylandsted2002Eradi-6858, title={Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion}, year={2002}, number={24}, volume={62}, issn={0008-5472}, journal={Cancer Research}, pages={7139--7142}, author={Nylandsted, Jesper and Wick, Wolfgang and Hirt, Ulrich and Brand, Karsten and Rohde, Mikkel and Leist, Marcel and Weller, Michael and Jäättelä, Marja} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/6858"> <dcterms:bibliographicCitation>First publ. in: Cancer Research ; 62 (2002), 24. - pp. 7139-7142</dcterms:bibliographicCitation> <dc:rights>deposit-license</dc:rights> <dcterms:abstract xml:lang="eng">Heat shock protein 70 (Hsp70) is an antiapoptotic chaperone protein highly expressed in human tumors. Here we demonstrate that locoregional application of adenovirus expressing antisense Hsp70 cDNA (Ad.asHsp70) eradicates orthotopic xenografts of glioblastoma and breast carcinoma, as well as s.c. xenografts of colon carcinoma in immunodeficient mice. Ad.asHsp70-treated tumors showed massive apoptosis-like cell death and recruitment of macrophages. Human monocyte-derived macrophages effectively removed the corpses of Ad.asHsp70-treated tumor cells in vitro. Interestingly, both tumor cell death and phagocytosis were caspaseindependent. Thus, Hsp70 appears as a promising target for the treatment of cancers resistant to classic caspase-mediated apoptosis.</dcterms:abstract> <dc:contributor>Wick, Wolfgang</dc:contributor> <dc:contributor>Brand, Karsten</dc:contributor> <dc:contributor>Nylandsted, Jesper</dc:contributor> <dc:contributor>Hirt, Ulrich</dc:contributor> <dc:creator>Leist, Marcel</dc:creator> <dc:contributor>Leist, Marcel</dc:contributor> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:format>application/pdf</dc:format> <dc:contributor>Jäättelä, Marja</dc:contributor> <dcterms:issued>2002</dcterms:issued> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6858"/> <dc:creator>Hirt, Ulrich</dc:creator> <dc:creator>Jäättelä, Marja</dc:creator> <dc:language>eng</dc:language> <dc:creator>Brand, Karsten</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:29:42Z</dcterms:available> <dc:creator>Wick, Wolfgang</dc:creator> <dc:creator>Nylandsted, Jesper</dc:creator> <dc:creator>Weller, Michael</dc:creator> <dc:creator>Rohde, Mikkel</dc:creator> <dcterms:title>Eradication of Glioblastoma, and Breast and Colon Carcinoma Xenografts by Hsp70 Depletion</dcterms:title> <dc:contributor>Rohde, Mikkel</dc:contributor> <dc:contributor>Weller, Michael</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:29:42Z</dc:date> </rdf:Description> </rdf:RDF>

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