Trying to understand axonal regeneration in the CNS of fish


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STÜRMER, Claudia, Martin BASTMEYER, Matthias BÄHR, Gabrielle STROBEL, Katja A. PASCHKE, 1992. Trying to understand axonal regeneration in the CNS of fish. In: Journal of Neurobiology. 23(5), pp. 537-550. ISSN 0022-3034. eISSN 1097-4695. Available under: doi: 10.1002/neu.480230508

@article{Sturmer1992Tryin-6847, title={Trying to understand axonal regeneration in the CNS of fish}, year={1992}, doi={10.1002/neu.480230508}, number={5}, volume={23}, issn={0022-3034}, journal={Journal of Neurobiology}, pages={537--550}, author={Stürmer, Claudia and Bastmeyer, Martin and Bähr, Matthias and Strobel, Gabrielle and Paschke, Katja A.} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:contributor>Paschke, Katja A.</dc:contributor> <dc:format>application/pdf</dc:format> <dcterms:bibliographicCitation>First publ. in: Journal of Neurobiology 23 (1992), 5, pp. 537-550</dcterms:bibliographicCitation> <dc:rights>terms-of-use</dc:rights> <dc:date rdf:datatype="">2011-03-24T17:29:37Z</dc:date> <dc:contributor>Bähr, Matthias</dc:contributor> <dspace:hasBitstream rdf:resource=""/> <bibo:uri rdf:resource=""/> <dcterms:hasPart rdf:resource=""/> <dcterms:issued>1992</dcterms:issued> <dc:contributor>Strobel, Gabrielle</dc:contributor> <dc:creator>Strobel, Gabrielle</dc:creator> <dc:creator>Bähr, Matthias</dc:creator> <dc:creator>Paschke, Katja A.</dc:creator> <dcterms:abstract xml:lang="deu">In contrast to the situation in mammals and birds, neurons in the central nervous system (CNS) of fish - such as the retinal ganglion cells - are capable of regenerating their axons and restoring vision. Special properties of the glial cells and the neurons of the fish visual pathway appear to contribute to the success of axonal regeneration. The fish oligodendrocytes lack the axon growth inhibiting molecules that interfere with axonal extension in mammals. Instead, fish optic nerve oligodendrocytes support - at least in vitro - axonal elongation of fish as well as that of rat retinal axons. Moreover, the fish retinal ganglion cells re-express upon injury a set of growth associated cell surface molecules and equip the regenerating axons throughout their path and up into their target, the tectum opticum with these molecules. This may indicate that the injured fish ganglion cells reactivate the cellular machinery necessary for axonal regrowth and pathfinding. Furthermore, the target itself provides positional marker molecules even in adult fish. These marker molecules are required to guide the regenerating axons back to their retinotopic home territory within the tectum.</dcterms:abstract> <dc:contributor>Stürmer, Claudia</dc:contributor> <dc:language>eng</dc:language> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource=""/> <dspace:isPartOfCollection rdf:resource=""/> <dcterms:available rdf:datatype="">2011-03-24T17:29:37Z</dcterms:available> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Bastmeyer, Martin</dc:creator> <dc:creator>Stürmer, Claudia</dc:creator> <dc:contributor>Bastmeyer, Martin</dc:contributor> <dcterms:title>Trying to understand axonal regeneration in the CNS of fish</dcterms:title> </rdf:Description> </rdf:RDF>

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