Localized Crystallization of Calcium Phosphates by Light‐Induced Processes

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2023
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Menichetti, Arianna
Montalti, Marco
García‐Ruiz, Juan Manuel
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Chemistry – A European Journal. Wiley. 2023, 29(67), e202302327. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.202302327
Zusammenfassung

Medical treatment options for bones and teeth can be significantly enhanced by taking control over the crystallization of biomaterials like hydroxyapatite in the healing process. Light‐induced techniques are particularly interesting for this approach as they offer tremendous accuracy in spatial resolution. However, in the field of calcium phosphates, light‐induced crystallization has not been investigated so far. Here, proof of principle is established to successfully induce carbonate‐hydroxyapatite precipitation by light irradiation. Phosphoric acid is released by a photolabile molecule exclusively after irradiation, combining with calcium ions to form a calcium phosphate in the crystallization medium. 4‐Nitrophenylphosphate (4NPP) is established as the photolabile molecule and the system is optimized and fully characterized. A calcium phosphate is crystallized exclusively by irradiation in aqueous solution and identified as carbonate apatite. Control over the localization and stabilization of the carbonate apatite is achieved by a pulsed laser, triggering precipitation in calcium and 4NPP‐containing gel matrices. The results of this communication open up a wide range of new opportunities, both in the field of chemistry for more sophisticated reaction control in localized crystallization processes and in the field of medicine for enhanced treatment of calcium phosphate containing biomaterials.

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540 Chemie
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General Chemistry, Catalysis, Organic Chemistry
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ISO 690BESIRSKE, Patricia, Arianna MENICHETTI, Marco MONTALTI, Juan Manuel GARCÍA‐RUIZ, Martin WINTERHALDER, Johannes BONEBERG, Helmut CÖLFEN, 2023. Localized Crystallization of Calcium Phosphates by Light‐Induced Processes. In: Chemistry – A European Journal. Wiley. 2023, 29(67), e202302327. ISSN 0947-6539. eISSN 1521-3765. Available under: doi: 10.1002/chem.202302327
BibTex
@article{Besirske2023-10-19Local-68100,
  year={2023},
  doi={10.1002/chem.202302327},
  title={Localized Crystallization of Calcium Phosphates by Light‐Induced Processes},
  number={67},
  volume={29},
  issn={0947-6539},
  journal={Chemistry – A European Journal},
  author={Besirske, Patricia and Menichetti, Arianna and Montalti, Marco and García‐Ruiz, Juan Manuel and Winterhalder, Martin and Boneberg, Johannes and Cölfen, Helmut},
  note={Article Number: e202302327}
}
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