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Molecular mechanism and structure of Trigger Factor bound to the translating ribosome

Molecular mechanism and structure of Trigger Factor bound to the translating ribosome

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MERZ, Frieder, Daniel BOEHRINGER, Christiane SCHAFFITZEL, Steffen PREISSLER, Anja HOFFMANN, Timm MAIER, Anna RUTKOWSKA, Jasmin LOZZA, Nenad BAN, Bernd BUKAU, Elke DEUERLING, 2008. Molecular mechanism and structure of Trigger Factor bound to the translating ribosome. In: The Embo Journal. 27(11), pp. 1622-1632. ISSN 0261-4189. eISSN 1460-2075

@article{Merz2008Molec-6807, title={Molecular mechanism and structure of Trigger Factor bound to the translating ribosome}, year={2008}, doi={10.1038/emboj.2008.89}, number={11}, volume={27}, issn={0261-4189}, journal={The Embo Journal}, pages={1622--1632}, author={Merz, Frieder and Boehringer, Daniel and Schaffitzel, Christiane and Preissler, Steffen and Hoffmann, Anja and Maier, Timm and Rutkowska, Anna and Lozza, Jasmin and Ban, Nenad and Bukau, Bernd and Deuerling, Elke} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/6807"> <dc:contributor>Maier, Timm</dc:contributor> <dc:contributor>Ban, Nenad</dc:contributor> <dc:creator>Rutkowska, Anna</dc:creator> <dc:rights>deposit-license</dc:rights> <dc:creator>Lozza, Jasmin</dc:creator> <dc:contributor>Hoffmann, Anja</dc:contributor> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:29:20Z</dcterms:available> <dc:format>application/pdf</dc:format> <dcterms:abstract xml:lang="eng">Ribosome-associated chaperone Trigger Factor (TF) initiates folding of newly synthesized proteins in bacteria. Here, we pinpoint by site-specific crosslinking the sequence of molecular interactions of Escherichia coli TF and nascent chains during translation. Furthermore, we provide the first full-length structure of TF associated with ribosome nascent chain complexes by using cryoelectron microscopy. In its active state, TF arches over the ribosomal exit tunnel accepting nascent chains in a protective void. The growing nascent chain initially follows a predefined path through the entire interior of TF in an unfolded conformation, and even after folding into a domain it remains accommodated inside the protective cavity of ribosome-bound TF. The adaptability to accept nascent chains of different length and folding states may explain how TF is able to assist co-translational folding of all kinds of nascent polypeptides during ongoing synthesis. Moreover, we suggest a model of how TF s chaperoning function can be coordinated with the co-translational processing and membrane targeting of nascent polypeptides by other ribosome-associated factors.</dcterms:abstract> <dc:contributor>Deuerling, Elke</dc:contributor> <dc:creator>Maier, Timm</dc:creator> <dc:contributor>Merz, Frieder</dc:contributor> <dc:creator>Merz, Frieder</dc:creator> <dc:contributor>Schaffitzel, Christiane</dc:contributor> <dc:creator>Schaffitzel, Christiane</dc:creator> <dc:contributor>Rutkowska, Anna</dc:contributor> <dcterms:bibliographicCitation>First publ. in: The Embo Journal 27 (2008), 11, pp. 1622-1632</dcterms:bibliographicCitation> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:29:20Z</dc:date> <dcterms:title>Molecular mechanism and structure of Trigger Factor bound to the translating ribosome</dcterms:title> <dcterms:issued>2008</dcterms:issued> <dc:contributor>Preissler, Steffen</dc:contributor> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6807"/> <dc:contributor>Lozza, Jasmin</dc:contributor> <dc:contributor>Boehringer, Daniel</dc:contributor> <dc:creator>Deuerling, Elke</dc:creator> <dc:creator>Preissler, Steffen</dc:creator> <dc:contributor>Bukau, Bernd</dc:contributor> <dc:creator>Ban, Nenad</dc:creator> <dc:creator>Hoffmann, Anja</dc:creator> <dc:creator>Bukau, Bernd</dc:creator> <dc:creator>Boehringer, Daniel</dc:creator> </rdf:Description> </rdf:RDF>

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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