Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells

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Datum
2023
Autor:innen
Carta, Giada
van der Stel, Wanda
Scuric, Emma W. J.
Capinha, Liliana
Bennekou, Susanne Hougaard
Forsby, Anna
Walker, Paul
van de Water, Bob
et al.
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European Union (EU): 681002
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EUToxRisk21
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Cell Biology and Toxicology. Springer. 2023, 39(6), pp. 3031-3059. ISSN 0742-2091. eISSN 1573-6822. Available under: doi: 10.1007/s10565-023-09816-7
Zusammenfassung

Analysis of the transcriptomic alterations upon chemical challenge, provides in depth mechanistic information on the compound’s toxic mode of action, by revealing specific pathway activation and other transcriptional modulations. Mapping changes in cellular behaviour to chemical insult, facilitates the characterisation of chemical hazard. In this study, we assessed the transcriptional landscape of mitochondrial impairment through the inhibition of the electron transport chain (ETC) in a human renal proximal tubular cell line (RPTEC/TERT1). We identified the unfolded protein response pathway (UPR), particularly the PERK/ATF4 branch as a common cellular response across ETC I, II and III inhibitions. This finding and the specific genes elaborated may aid the identification of mitochondrial liabilities of chemicals in both legacy data and prospective transcriptomic studies.

Zusammenfassung in einer weiteren Sprache
Fachgebiet (DDC)
570 Biowissenschaften, Biologie
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Mitochondria, In vitro, Renal, Stress pathway, Transcriptomic
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ISO 690CARTA, Giada, Wanda VAN DER STEL, Emma W. J. SCURIC, Liliana CAPINHA, Johannes DELP, Susanne Hougaard BENNEKOU, Anna FORSBY, Paul WALKER, Marcel LEIST, Bob VAN DE WATER, 2023. Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells. In: Cell Biology and Toxicology. Springer. 2023, 39(6), pp. 3031-3059. ISSN 0742-2091. eISSN 1573-6822. Available under: doi: 10.1007/s10565-023-09816-7
BibTex
@article{Carta2023-06-23Trans-67523,
  year={2023},
  doi={10.1007/s10565-023-09816-7},
  title={Transcriptional landscape of mitochondrial electron transport chain inhibition in renal cells},
  number={6},
  volume={39},
  issn={0742-2091},
  journal={Cell Biology and Toxicology},
  pages={3031--3059},
  author={Carta, Giada and van der Stel, Wanda and Scuric, Emma W. J. and Capinha, Liliana and Delp, Johannes and Bennekou, Susanne Hougaard and Forsby, Anna and Walker, Paul and Leist, Marcel and van de Water, Bob}
}
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