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Preformed reggie/flotillin caps : stable priming platforms for macrodomain assembly in T cells

Preformed reggie/flotillin caps : stable priming platforms for macrodomain assembly in T cells

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LANGHORST, Matthias F., Alexander REUTER, Georg LUXENHOFER, Eva-Maria BONEBERG, Daniel F. LEGLER, Helmut PLATTNER, Claudia STÜRMER, 2006. Preformed reggie/flotillin caps : stable priming platforms for macrodomain assembly in T cells. In: The FASEB Journal. 20(6), pp. 711-3-713. ISSN 0892-6638. eISSN 1530-6860

@article{Langhorst2006-04Prefo-6738, title={Preformed reggie/flotillin caps : stable priming platforms for macrodomain assembly in T cells}, year={2006}, doi={10.1096/fj.05-4760fje}, number={6}, volume={20}, issn={0892-6638}, journal={The FASEB Journal}, pages={711-3--713}, author={Langhorst, Matthias F. and Reuter, Alexander and Luxenhofer, Georg and Boneberg, Eva-Maria and Legler, Daniel F. and Plattner, Helmut and Stürmer, Claudia} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/6738"> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:28:50Z</dcterms:available> <dcterms:bibliographicCitation>First publ. in: The FASEB Journal ; 20 (2006), 6. - S. 711-713</dcterms:bibliographicCitation> <dc:contributor>Legler, Daniel F.</dc:contributor> <dc:rights>deposit-license</dc:rights> <dcterms:issued>2006-04</dcterms:issued> <dc:creator>Boneberg, Eva-Maria</dc:creator> <dc:language>eng</dc:language> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6738"/> <dcterms:title>Preformed reggie/flotillin caps : stable priming platforms for macrodomain assembly in T cells</dcterms:title> <dc:format>application/pdf</dc:format> <dc:creator>Luxenhofer, Georg</dc:creator> <dc:creator>Legler, Daniel F.</dc:creator> <dc:contributor>Boneberg, Eva-Maria</dc:contributor> <dc:contributor>Langhorst, Matthias F.</dc:contributor> <dc:creator>Stürmer, Claudia</dc:creator> <dc:contributor>Luxenhofer, Georg</dc:contributor> <dc:creator>Plattner, Helmut</dc:creator> <dc:creator>Reuter, Alexander</dc:creator> <dc:contributor>Reuter, Alexander</dc:contributor> <dc:contributor>Stürmer, Claudia</dc:contributor> <dcterms:abstract xml:lang="eng">T cell activation after contact with an antigen-presenting cell depends on the regulated assembly of the T cell receptor signaling complex, which involves the polarized assembly of a stable, raftlike macrodomain surrounding engaged T cell receptors. Here we show that the preformed reggie/flotillin caps present in resting T cells act as priming platforms for macrodomain assembly. Preformed reggie-1/flotillin-2 caps are exceptionally stable, as shown by fluorescence recovery after photobleaching (FRAP). Upon T cell stimulation, signaling molecules are recruited to the stable reggie/flotillin caps. Importantly, a trans-negative reggie-1/flotillin-2 deletion mutant, which interferes with assembly of the preformed reggie/flotillin cap, impairs raft polarization and macrodomain formation after T cell activation. Accordingly, expression of the trans-negative reggie-1 mutant leads to the incorrect positioning of the guanine nucleotide exchange factor Vav, resulting in defects in cytoskeletal reorganization. Thus, the preformed reggie/flotillin caps are stable priming platforms for the assembly of multiprotein complexes controlling actin reorganization during T cell activation.</dcterms:abstract> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:28:50Z</dc:date> <dc:contributor>Plattner, Helmut</dc:contributor> <dc:creator>Langhorst, Matthias F.</dc:creator> </rdf:Description> </rdf:RDF>

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