An evolutionary basis for scrapie disease : identification of a fish prion mRNA

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RIVERA-MILLA, Eric, Claudia STÜRMER, Edward MÁLAGA-TRILLO, 2003. An evolutionary basis for scrapie disease : identification of a fish prion mRNA. In: Trends in Genetics. 19(2), pp. 72-75. ISSN 0168-9525

@article{Rivera-Milla2003evolu-6715, title={An evolutionary basis for scrapie disease : identification of a fish prion mRNA}, year={2003}, doi={10.1016/S0168-9525(02)00032-X}, number={2}, volume={19}, issn={0168-9525}, journal={Trends in Genetics}, pages={72--75}, author={Rivera-Milla, Eric and Stürmer, Claudia and Málaga-Trillo, Edward} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/6715"> <dc:creator>Rivera-Milla, Eric</dc:creator> <dc:format>application/pdf</dc:format> <dcterms:issued>2003</dcterms:issued> <dcterms:abstract xml:lang="eng">Infectious prion proteins cause neurodegenerative disease in mammals owing to the acquisition of an aberrant conformation. We cloned a Fugu rubripes gene that encodes a structurally conserved prion protein, and found rapid rates of molecular divergence among prions from different vertebrate classes, along with molecular stasis within each class. We propose that a directional trend in the evolution of prion sequence motifs associated with pathogenesis and infectivity could account for the origin of scrapie in mammals.</dcterms:abstract> <dc:language>eng</dc:language> <dcterms:title>An evolutionary basis for scrapie disease : identification of a fish prion mRNA</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:28:38Z</dc:date> <dcterms:rights rdf:resource="https://creativecommons.org/licenses/by-nc-nd/2.0/legalcode"/> <dc:contributor>Stürmer, Claudia</dc:contributor> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:28:38Z</dcterms:available> <dc:contributor>Málaga-Trillo, Edward</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Trends in Genetics 19 (2003), 2, pp. 72-75</dcterms:bibliographicCitation> <dc:rights>deposit-license</dc:rights> <dc:creator>Málaga-Trillo, Edward</dc:creator> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6715"/> <dc:contributor>Rivera-Milla, Eric</dc:contributor> <dc:creator>Stürmer, Claudia</dc:creator> </rdf:Description> </rdf:RDF>

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