Poly(ADP-ribosyl)ation in mammalian ageing

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BENEKE, Sascha, Alexander BÜRKLE, 2007. Poly(ADP-ribosyl)ation in mammalian ageing. In: Nucleic Acids Research. 35(22), pp. 7456-7465. eISSN 1539-6150

@article{Beneke2007Poly(-6615, title={Poly(ADP-ribosyl)ation in mammalian ageing}, year={2007}, doi={10.1126/sageke.2004.49.re9}, number={22}, volume={35}, journal={Nucleic Acids Research}, pages={7456--7465}, author={Beneke, Sascha and Bürkle, Alexander} }

<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/6615"> <dcterms:rights rdf:resource="http://nbn-resolving.org/urn:nbn:de:bsz:352-20140905103416863-3868037-7"/> <bibo:uri rdf:resource="http://kops.uni-konstanz.de/handle/123456789/6615"/> <dc:format>application/pdf</dc:format> <dc:rights>deposit-license</dc:rights> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:27:48Z</dcterms:available> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2011-03-24T17:27:48Z</dc:date> <dcterms:abstract xml:lang="eng">Poly(ADP-ribose) polymerases (PARPs) catalyze the post-translational modification of proteins with poly(ADP-ribose). Two PARP isoforms, PARP-1 and PARP-2, display catalytic activity by contact with DNA-strand breaks and are involved in DNA baseexcision repair and other repair pathways. A body of correlative data suggests a link between damage-induced poly(ADP-ribosyl)ation and mammalian longevity. Recent research on PARPs and poly(ADP-ribose) yielded several candidate mechanisms through which poly(ADP-ribosyl)ation might act as a factor that limits the rate of ageing.</dcterms:abstract> <dc:contributor>Beneke, Sascha</dc:contributor> <dc:contributor>Bürkle, Alexander</dc:contributor> <dcterms:bibliographicCitation>First publ. in: Nucleic Acids Research 35 (2007), 22, pp. 7456-7465</dcterms:bibliographicCitation> <dc:language>eng</dc:language> <dc:creator>Beneke, Sascha</dc:creator> <dcterms:issued>2007</dcterms:issued> <dc:creator>Bürkle, Alexander</dc:creator> <dcterms:title>Poly(ADP-ribosyl)ation in mammalian ageing</dcterms:title> </rdf:Description> </rdf:RDF>

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