Abnormal resting-state cortical coupling in chronic Tinnitus


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SCHLEE, Winfried, Thomas HARTMANN, Berthold LANGGUTH, Nathan WEISZ, 2009. Abnormal resting-state cortical coupling in chronic Tinnitus. In: BMC Neuroscience. 10(1), 11. eISSN 1471-2202

@article{Schlee2009Abnor-6481, title={Abnormal resting-state cortical coupling in chronic Tinnitus}, year={2009}, doi={10.1186/1471-2202-10-11}, number={1}, volume={10}, journal={BMC Neuroscience}, author={Schlee, Winfried and Hartmann, Thomas and Langguth, Berthold and Weisz, Nathan}, note={Article Number: 11} }

First publ. in: BMC Neuroscience 2009, 10:11 deposit-license application/pdf Hartmann, Thomas Abnormal resting-state cortical coupling in chronic Tinnitus 2009 Langguth, Berthold Weisz, Nathan Schlee, Winfried Hartmann, Thomas Background:<br />Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference is expressed by differential activation of distributed cortical networks.<br />Results:<br />The analysis was based on a sample of 41 participants: 21 patients with chronic tinnitus and 20 healthy control participants. To investigate the architecture of these networks, we used phase locking analysis in the 1 90 Hz frequency range of a minute of resting-state MEG recording. We found: 1) For tinnitus patients: A significant decrease of inter-areal coupling in the alpha (9 12 Hz) band and an increase of inter-areal coupling in the 48 54 Hz gamma frequency range relative to the control group. 2) For both groups: an inverse relationship (r = -.71) of the alpha and gamma network coupling. 3) A discrimination of 83% between the patient and the control group based on the alpha and gamma networks. 4) An effect of manifestation on the distribution of the gamma network: In patients with a tinnitus history of less than 4 years, the left temporal cortex was predominant in the gamma network whereas in patients with tinnitus duration of more than 4 years, the gamma network was more widely distributed including more frontal and parietal regions.<br />Conclusion:<br />In the here presented data set we found strong support for an alteration of long-range coupling in tinnitus. Long-range coupling in the alpha frequency band was decreased for tinnitus patients while long-range gamma coupling was increased. These changes discriminate well between tinnitus and control participants. We propose a tinnitus model that integrates this finding in the current knowledge about tinnitus. Furthermore we discuss the impact of this finding to tinnitus therapies using Transcranial Magnetic Stimulation (TMS). Weisz, Nathan 2011-03-24T16:53:32Z eng Langguth, Berthold 2011-03-24T16:53:32Z Schlee, Winfried

Dateiabrufe seit 01.10.2014 (Informationen über die Zugriffsstatistik)

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