Abnormal resting-state cortical coupling in chronic Tinnitus

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SCHLEE, Winfried, Thomas HARTMANN, Berthold LANGGUTH, Nathan WEISZ, 2009. Abnormal resting-state cortical coupling in chronic Tinnitus. In: BMC Neuroscience. 10(1), 11. eISSN 1471-2202. Available under: doi: 10.1186/1471-2202-10-11

@article{Schlee2009Abnor-6481, title={Abnormal resting-state cortical coupling in chronic Tinnitus}, year={2009}, doi={10.1186/1471-2202-10-11}, number={1}, volume={10}, journal={BMC Neuroscience}, author={Schlee, Winfried and Hartmann, Thomas and Langguth, Berthold and Weisz, Nathan}, note={Article Number: 11} }

First publ. in: BMC Neuroscience 2009, 10:11 application/pdf deposit-license Hartmann, Thomas Abnormal resting-state cortical coupling in chronic Tinnitus 2009 Langguth, Berthold Weisz, Nathan Hartmann, Thomas Schlee, Winfried Background:<br />Subjective tinnitus is characterized by an auditory phantom perception in the absence of any physical sound source. Consequently, in a quiet environment, tinnitus patients differ from control participants because they constantly perceive a sound whereas controls do not. We hypothesized that this difference is expressed by differential activation of distributed cortical networks.<br />Results:<br />The analysis was based on a sample of 41 participants: 21 patients with chronic tinnitus and 20 healthy control participants. To investigate the architecture of these networks, we used phase locking analysis in the 1 90 Hz frequency range of a minute of resting-state MEG recording. We found: 1) For tinnitus patients: A significant decrease of inter-areal coupling in the alpha (9 12 Hz) band and an increase of inter-areal coupling in the 48 54 Hz gamma frequency range relative to the control group. 2) For both groups: an inverse relationship (r = -.71) of the alpha and gamma network coupling. 3) A discrimination of 83% between the patient and the control group based on the alpha and gamma networks. 4) An effect of manifestation on the distribution of the gamma network: In patients with a tinnitus history of less than 4 years, the left temporal cortex was predominant in the gamma network whereas in patients with tinnitus duration of more than 4 years, the gamma network was more widely distributed including more frontal and parietal regions.<br />Conclusion:<br />In the here presented data set we found strong support for an alteration of long-range coupling in tinnitus. Long-range coupling in the alpha frequency band was decreased for tinnitus patients while long-range gamma coupling was increased. These changes discriminate well between tinnitus and control participants. We propose a tinnitus model that integrates this finding in the current knowledge about tinnitus. Furthermore we discuss the impact of this finding to tinnitus therapies using Transcranial Magnetic Stimulation (TMS). 2011-03-24T16:53:32Z Weisz, Nathan Langguth, Berthold eng 2011-03-24T16:53:32Z Schlee, Winfried

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