Development of an Evidence-Based Risk Assessment Framework

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KREWSKI, Daniel, Patrick SAUNDERS-HASTINGS, Robert A. BAAN, Tara S. BARTON-MACLAREN, Patience BROWNE, Weihsueh A. CHIU, Maureen GWINN, Thomas HARTUNG, Andrew D. KRAFT, Juleen LAM, 2022. Development of an Evidence-Based Risk Assessment Framework. In: Alternatives to Animal Experimentation : ALTEX. Springer Spektrum. 39(4), pp. 667-693. ISSN 1868-596X. eISSN 1868-8551. Available under: doi: 10.14573/altex.2004041

@article{Krewski2022Devel-59459, title={Development of an Evidence-Based Risk Assessment Framework}, year={2022}, doi={10.14573/altex.2004041}, number={4}, volume={39}, issn={1868-596X}, journal={Alternatives to Animal Experimentation : ALTEX}, pages={667--693}, author={Krewski, Daniel and Saunders-Hastings, Patrick and Baan, Robert A. and Barton-Maclaren, Tara S. and Browne, Patience and Chiu, Weihsueh A. and Gwinn, Maureen and Hartung, Thomas and Kraft, Andrew D. and Lam, Juleen} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dc:creator>Saunders-Hastings, Patrick</dc:creator> <dc:contributor>Gwinn, Maureen</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Kraft, Andrew D.</dc:creator> <dc:rights>terms-of-use</dc:rights> <dc:creator>Gwinn, Maureen</dc:creator> <dspace:isPartOfCollection rdf:resource=""/> <dc:contributor>Barton-Maclaren, Tara S.</dc:contributor> <dc:creator>Baan, Robert A.</dc:creator> <dcterms:abstract xml:lang="eng">Assessment of potential human health risks associated with environmental and other agents requires careful evaluation of all available and relevant evidence for the agent of interest, including both data-rich and data-poor agents. With the advent of new approach methodologies in toxicological risk assessment, guidance on integrating evidence from mul-tiple evidence streams is needed to ensure that all available data is given due consideration in both qualitative and quantitative risk assessment. The present report summarizes the discussions among academic, government, and private sector participants from North America and Europe in an international workshop convened to explore the development of an evidence-based risk assessment framework, taking into account all available evidence in an appropriate manner in order to arrive at the best possible characterization of potential human health risks and associated uncertainty. Although consensus among workshop participants was not a specific goal, there was general agreement on the key consider-ations involved in evidence-based risk assessment incorporating 21st century science into human health risk assessment. These considerations have been embodied into an overarching prototype framework for evidence integration that will be explored in more depth in a follow-up meeting.</dcterms:abstract> <dc:creator>Barton-Maclaren, Tara S.</dc:creator> <dc:contributor>Hartung, Thomas</dc:contributor> <dc:contributor>Lam, Juleen</dc:contributor> <dc:contributor>Saunders-Hastings, Patrick</dc:contributor> <dc:creator>Lam, Juleen</dc:creator> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Browne, Patience</dc:creator> <dc:language>eng</dc:language> <dc:date rdf:datatype="">2022-12-08T11:58:35Z</dc:date> <dcterms:issued>2022</dcterms:issued> <dcterms:available rdf:datatype="">2022-12-08T11:58:35Z</dcterms:available> <dc:creator>Chiu, Weihsueh A.</dc:creator> <bibo:uri rdf:resource=""/> <dspace:hasBitstream rdf:resource=""/> <dc:contributor>Chiu, Weihsueh A.</dc:contributor> <dc:contributor>Browne, Patience</dc:contributor> <dc:creator>Hartung, Thomas</dc:creator> <dc:creator>Krewski, Daniel</dc:creator> <dc:contributor>Krewski, Daniel</dc:contributor> <dc:contributor>Baan, Robert A.</dc:contributor> <dc:contributor>Kraft, Andrew D.</dc:contributor> <dcterms:title>Development of an Evidence-Based Risk Assessment Framework</dcterms:title> <dcterms:hasPart rdf:resource=""/> <dcterms:rights rdf:resource=""/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> </rdf:Description> </rdf:RDF>

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