Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma

Ande, Sudharsana Rao; Fussi, Heike; Knauer, Heide; Murkovic, Michael; Ghisla, Sandro; Fröhlich, Kai-Uwe; Macheroux, Peter

Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma

Dateien

Zu diesem Dokument gibt es keine Dateien.

Datum

2008

Autor:innen

Ande, Sudharsana Rao

Fussi, Heike

Knauer, Heide

Murkovic, Michael

Ghisla, Sandro

Fröhlich, Kai-Uwe

Macheroux, Peter

DOI (zitierfähiger Link)

https://doi.org/10.1002/yea.1592

Sammlungen

Biologie

Publikationstyp

Zeitschriftenartikel

Publikationsstatus

Published

Erschienen in

Yeast. Wiley-Blackwell. 2008, 25(5), pp. 349-357. ISSN 0749-503X. eISSN 1097-0061. Available under: doi: 10.1002/yea.1592

Zusammenfassung

Here we report for the first time that L-amino acid oxidase (LAAO), a major component of snake venom, induces apoptosis in yeast. The causative agent for induction of apoptosis has been shown to be hydrogen peroxide, produced by the enzymatic activity of LAAO. However, the addition of catalase, a specific hydrogen peroxide scavenger, does not prevent cell demise completely. Intriguingly, depletion of leucine from the medium by LAAO and the interaction of LAAO with yeast cells are shown to be the major factors responsible for cell demise in the presence of catalase.

Fachgebiet (DDC)

570 Biowissenschaften, Biologie

Zitieren

ISO 690

ANDE, Sudharsana Rao, Heike FUSSI, Heide KNAUER, Michael MURKOVIC, Sandro GHISLA, Kai-Uwe FRÖHLICH, Peter MACHEROUX, 2008. Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma. In: Yeast. Wiley-Blackwell. 2008, 25(5), pp. 349-357. ISSN 0749-503X. eISSN 1097-0061. Available under: doi: 10.1002/yea.1592

BibTex

@article{Ande2008-05Induc-58672,
  year={2008},
  doi={10.1002/yea.1592},
  title={Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma},
  number={5},
  volume={25},
  issn={0749-503X},
  journal={Yeast},
  pages={349--357},
  author={Ande, Sudharsana Rao and Fussi, Heike and Knauer, Heide and Murkovic, Michael and Ghisla, Sandro and Fröhlich, Kai-Uwe and Macheroux, Peter}
}

RDF

<rdf:RDF
    xmlns:dcterms="http://purl.org/dc/terms/"
    xmlns:dc="http://purl.org/dc/elements/1.1/"
    xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
    xmlns:bibo="http://purl.org/ontology/bibo/"
    xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#"
    xmlns:foaf="http://xmlns.com/foaf/0.1/"
    xmlns:void="http://rdfs.org/ns/void#"
    xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > 
  <rdf:Description rdf:about="https://kops.uni-konstanz.de/server/rdf/resource/123456789/58672">
    <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-21T13:17:37Z</dcterms:available>
    <dc:contributor>Macheroux, Peter</dc:contributor>
    <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <dc:contributor>Ghisla, Sandro</dc:contributor>
    <dcterms:title>Induction of apoptosis in yeast by L-amino acid oxidase from the Malayan pit viper Calloselasma rhodostoma</dcterms:title>
    <dc:contributor>Knauer, Heide</dc:contributor>
    <dc:creator>Ghisla, Sandro</dc:creator>
    <dc:contributor>Murkovic, Michael</dc:contributor>
    <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/58672"/>
    <dc:contributor>Ande, Sudharsana Rao</dc:contributor>
    <dc:contributor>Fröhlich, Kai-Uwe</dc:contributor>
    <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/server/rdf/resource/123456789/28"/>
    <foaf:homepage rdf:resource="http://localhost:8080/"/>
    <dc:contributor>Fussi, Heike</dc:contributor>
    <dcterms:issued>2008-05</dcterms:issued>
    <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/>
    <dc:creator>Fussi, Heike</dc:creator>
    <dc:creator>Murkovic, Michael</dc:creator>
    <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-21T13:17:37Z</dc:date>
    <dc:creator>Ande, Sudharsana Rao</dc:creator>
    <dc:creator>Knauer, Heide</dc:creator>
    <dc:creator>Macheroux, Peter</dc:creator>
    <dc:language>eng</dc:language>
    <dcterms:abstract xml:lang="eng">Here we report for the first time that L-amino acid oxidase (LAAO), a major component of snake venom, induces apoptosis in yeast. The causative agent for induction of apoptosis has been shown to be hydrogen peroxide, produced by the enzymatic activity of LAAO. However, the addition of catalase, a specific hydrogen peroxide scavenger, does not prevent cell demise completely. Intriguingly, depletion of leucine from the medium by LAAO and the interaction of LAAO with yeast cells are shown to be the major factors responsible for cell demise in the presence of catalase.</dcterms:abstract>
    <dc:creator>Fröhlich, Kai-Uwe</dc:creator>
  </rdf:Description>
</rdf:RDF>

Universitätsbibliographie

Ja

Begutachtet

Ja