Syntheses and properties of pterin ribonucleosides

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

PFADLER, Werner, Wolfgang PFLEIDERER, 2008. Syntheses and properties of pterin ribonucleosides. In: Arkivoc. Arkat(3), pp. 95-114. ISSN 1551-7012. eISSN 1551-7004. Available under: doi: 10.3998/ark.5550190.0010.309

@article{Pfadler2008Synth-58595, title={Syntheses and properties of pterin ribonucleosides}, year={2008}, doi={10.3998/ark.5550190.0010.309}, number={3}, issn={1551-7012}, journal={Arkivoc}, pages={95--114}, author={Pfadler, Werner and Pfleiderer, Wolfgang} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/58595"> <dcterms:title>Syntheses and properties of pterin ribonucleosides</dcterms:title> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-12T08:00:42Z</dc:date> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-12T08:00:42Z</dcterms:available> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/58595"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:issued>2008</dcterms:issued> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Pfadler, Werner</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:language>eng</dc:language> <dc:contributor>Pfleiderer, Wolfgang</dc:contributor> <dc:creator>Pfleiderer, Wolfgang</dc:creator> <dc:contributor>Pfadler, Werner</dc:contributor> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dcterms:abstract xml:lang="eng">Several pterin derivatives (1-8) have been ribosylated in form of their trimethylsilyl derivatives (9) with 1-bromo-(10) and 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose (11) under the catalysis of HgO/HgBr 2 , BF3 -etherate and trimethylsilyl triflate, respectively. Mixtures of the N-1- (19-25) and N-3-ribofuranosides (12-18) which are difficult to be separated were obtained. Debenzoylation by the Zemplen method led to the free pterin-nucleosides (28-30). A second approach starting from 2-methylthio-4(3H)pteridinones (31-33) gave again mixtures of the N-1-(35-37) and N-3-ribonucleosides (38-40). The 2-methylthio function in 35-37 can easily be substituted by various amines leading after subsequently debenzoylation to the N-2- substituted pterin-ribonucleosides (41-50). The structural assignments were based on comparisons of the UV spectra with the corresponding N-methyl substituted model substances. 1 H-NMR-spectra functioned as additional structural proof.</dcterms:abstract> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Search KOPS


Browse

My Account