Shell microelectrode arrays (MEAs) for brain organoids

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HUANG, Qi, Bohao TANG, July Carolina ROMERO, Yuqian YANG, Saifeldeen Khalil ELSAYED, Gayatri PAHAPALE, Tien-Jung LEE, Itzy E. MORALES PANTOJA, Fang HAN, Cynthia BERLINICKE, Terry XIANG, Mallory SOLAZZO, Thomas HARTUNG, Zhao QIN, Brian S. CAFFO, Lena SMIRNOVA, David H. GRACIAS, 2022. Shell microelectrode arrays (MEAs) for brain organoids. In: Science Advances. American Association for the Advancement of Science (AAAS). 8(33), eabq5031. eISSN 2375-2548. Available under: doi: 10.1126/sciadv.abq5031

@article{Huang2022Shell-58502, title={Shell microelectrode arrays (MEAs) for brain organoids}, year={2022}, doi={10.1126/sciadv.abq5031}, number={33}, volume={8}, journal={Science Advances}, author={Huang, Qi and Tang, Bohao and Romero, July Carolina and Yang, Yuqian and Elsayed, Saifeldeen Khalil and Pahapale, Gayatri and Lee, Tien-Jung and Morales Pantoja, Itzy E. and Han, Fang and Berlinicke, Cynthia and Xiang, Terry and Solazzo, Mallory and Hartung, Thomas and Qin, Zhao and Caffo, Brian S. and Smirnova, Lena and Gracias, David H.}, note={Article Number: eabq5031} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/58502"> <dc:contributor>Elsayed, Saifeldeen Khalil</dc:contributor> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-06T09:22:15Z</dc:date> <dc:contributor>Pahapale, Gayatri</dc:contributor> <dc:contributor>Caffo, Brian S.</dc:contributor> <dc:creator>Caffo, Brian S.</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:language>eng</dc:language> <dc:contributor>Morales Pantoja, Itzy E.</dc:contributor> <dc:creator>Berlinicke, Cynthia</dc:creator> <dc:creator>Yang, Yuqian</dc:creator> <dc:creator>Elsayed, Saifeldeen Khalil</dc:creator> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-09-06T09:22:15Z</dcterms:available> <dc:creator>Morales Pantoja, Itzy E.</dc:creator> <dc:creator>Qin, Zhao</dc:creator> <dc:contributor>Huang, Qi</dc:contributor> <dc:contributor>Han, Fang</dc:contributor> <dcterms:abstract xml:lang="eng">Brain organoids are important models for mimicking some three-dimensional (3D) cytoarchitectural and functional aspects of the brain. Multielectrode arrays (MEAs) that enable recording and stimulation of activity from electrogenic cells offer notable potential for interrogating brain organoids. However, conventional MEAs, initially designed for monolayer cultures, offer limited recording contact area restricted to the bottom of the 3D organoids. Inspired by the shape of electroencephalography caps, we developed miniaturized wafer-integrated MEA caps for organoids. The optically transparent shells are composed of self-folding polymer leaflets with conductive polymer-coated metal electrodes. Tunable folding of the minicaps' polymer leaflets guided by mechanics simulations enables versatile recording from organoids of different sizes, and we validate the feasibility of electrophysiology recording from 400- to 600-μm-sized organoids for up to 4 weeks and in response to glutamate stimulation. Our studies suggest that 3D shell MEAs offer great potential for high signal-to-noise ratio and 3D spatiotemporal brain organoid recording.</dcterms:abstract> <dc:contributor>Qin, Zhao</dc:contributor> <dc:creator>Pahapale, Gayatri</dc:creator> <dc:contributor>Gracias, David H.</dc:contributor> <dc:creator>Lee, Tien-Jung</dc:creator> <dc:creator>Xiang, Terry</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:contributor>Solazzo, Mallory</dc:contributor> <dc:creator>Solazzo, Mallory</dc:creator> <dc:contributor>Smirnova, Lena</dc:contributor> <dc:contributor>Hartung, Thomas</dc:contributor> <dc:contributor>Tang, Bohao</dc:contributor> <dcterms:title>Shell microelectrode arrays (MEAs) for brain organoids</dcterms:title> <dc:contributor>Xiang, Terry</dc:contributor> <dc:creator>Romero, July Carolina</dc:creator> <dc:creator>Han, Fang</dc:creator> <dc:creator>Hartung, Thomas</dc:creator> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Romero, July Carolina</dc:contributor> <dc:contributor>Yang, Yuqian</dc:contributor> <dc:creator>Huang, Qi</dc:creator> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/58502"/> <dc:contributor>Lee, Tien-Jung</dc:contributor> <dc:creator>Smirnova, Lena</dc:creator> <dcterms:issued>2022</dcterms:issued> <dc:creator>Tang, Bohao</dc:creator> <dc:contributor>Berlinicke, Cynthia</dc:contributor> <dc:creator>Gracias, David H.</dc:creator> </rdf:Description> </rdf:RDF>

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