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Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation

Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation

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ROSSATTI, Pascal, Gregory M. I. REDPATH, Luca ZIEGLER, Guerric P. B. SAMSON, Camille D. CLAMAGIRAND, Daniel F. LEGLER, Jérémie ROSSY, 2022. Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation. In: BMC Biology. BioMed Central. 20(1), 189. eISSN 1741-7007. Available under: doi: 10.1186/s12915-022-01386-0

@article{Rossatti2022Rapid-58486, title={Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation}, year={2022}, doi={10.1186/s12915-022-01386-0}, number={1}, volume={20}, journal={BMC Biology}, author={Rossatti, Pascal and Redpath, Gregory M. I. and Ziegler, Luca and Samson, Guerric P. B. and Clamagirand, Camille D. and Legler, Daniel F. and Rossy, Jérémie}, note={Article Number: 189} }

Ziegler, Luca Samson, Guerric P. B. eng Redpath, Gregory M. I. Rossy, Jérémie Clamagirand, Camille D. Rapid increase in transferrin receptor recycling promotes adhesion during T cell activation Rossy, Jérémie Redpath, Gregory M. I. Attribution 4.0 International Samson, Guerric P. B. 2022 Background<br />T cell activation leads to increased expression of the receptor for the iron transporter transferrin (TfR) to provide iron required for the cell differentiation and clonal expansion that takes place during the days after encounter with a cognate antigen. However, T cells mobilise TfR to their surface within minutes after activation, although the reason and mechanism driving this process remain unclear.<br /><br />Results<br />Here we show that T cells transiently increase endocytic uptake and recycling of TfR upon activation, thereby boosting their capacity to import iron. We demonstrate that increased TfR recycling is powered by a fast endocytic sorting pathway relying on the membrane proteins flotillins, Rab5- and Rab11a-positive endosomes. Our data further reveal that iron import is required for a non-canonical signalling pathway involving the kinases Zap70 and PAK, which controls adhesion of the integrin LFA-1 and eventually leads to conjugation with antigen-presenting cells.<br /><br />Conclusions<br />Altogether, our data suggest that T cells boost their iron importing capacity immediately upon activation to promote adhesion to antigen-presenting cells. Ziegler, Luca Rossatti, Pascal Rossatti, Pascal Legler, Daniel F. Legler, Daniel F. 2022-09-05T07:24:36Z Clamagirand, Camille D. 2022-09-05T07:24:36Z

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