KOPS - The Institutional Repository of the University of Konstanz

Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis

Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis

Cite This

Files in this item

Files Size Format View

There are no files associated with this item.

BARRA, Lena, Takayoshi AWAKAWA, Ikuro ABE, 2022. Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis. In: JACS Au. American Chemical Society (ACS). eISSN 2691-3704. Available under: doi: 10.1021/jacsau.2c00391

@article{Barra2022-08-17Nonca-58430, title={Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis}, year={2022}, doi={10.1021/jacsau.2c00391}, journal={JACS Au}, author={Barra, Lena and Awakawa, Takayoshi and Abe, Ikuro} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/58430"> <dc:creator>Abe, Ikuro</dc:creator> <dc:creator>Barra, Lena</dc:creator> <dc:contributor>Awakawa, Takayoshi</dc:contributor> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/> <dc:contributor>Barra, Lena</dc:contributor> <dcterms:abstract xml:lang="eng">Enzymes involved in secondary metabolite biosynthetic pathways have typically evolutionarily diverged from their counterparts functioning in primary metabolism. They often catalyze diverse and complex chemical transformations and are thus a treasure trove for the discovery of unique enzyme-mediated chemistries. Besides major natural product classes, such as terpenoids, polyketides, and ribosomally or nonribosomally synthesized peptides, biosynthetic investigations of noncanonical natural product biosynthetic pathways often reveal functionally distinct enzyme chemistries. In this Perspective, we aim to highlight challenges and opportunities of biosynthetic investigations on noncanonical natural product pathways that utilize primary metabolites as building blocks, otherwise generally considered as enzyme cofactors. A focus is made on the discovered chemical and enzymological novelties.</dcterms:abstract> <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-08-30T13:02:40Z</dc:date> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:creator>Awakawa, Takayoshi</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Noncanonical Functions of Enzyme Cofactors as Building Blocks in Natural Product Biosynthesis</dcterms:title> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/29"/> <dc:contributor>Abe, Ikuro</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/58430"/> <dc:language>eng</dc:language> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-08-30T13:02:40Z</dcterms:available> <dcterms:issued>2022-08-17</dcterms:issued> </rdf:Description> </rdf:RDF>

This item appears in the following Collection(s)

Attribution-NonCommercial-NoDerivatives 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International

Search KOPS


Browse

My Account