KOPS - The Institutional Repository of the University of Konstanz

LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance

Cite This

Files in this item

Checksum: MD5:d46ad096ee236ac0bce160feed2e7c91

MICHALEK, Svenja, Thomas GOJ, Anna Pia PLAZZO, Blerim MAROVCA, Beat BORNHAUSER, Thomas BRUNNER, 2022. LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance. In: EMBO reports. EMBO Press. 23(9). ISSN 1469-221X. eISSN 1469-3178. Available under: doi: 10.15252/embr.202154195

@article{Michalek2022-09-05LRH1N-57992, title={LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance}, year={2022}, doi={10.15252/embr.202154195}, number={9}, volume={23}, issn={1469-221X}, journal={EMBO reports}, author={Michalek, Svenja and Goj, Thomas and Plazzo, Anna Pia and Marovca, Blerim and Bornhauser, Beat and Brunner, Thomas} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/57992"> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dc:contributor>Brunner, Thomas</dc:contributor> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-07-08T12:23:06Z</dc:date> <dc:contributor>Goj, Thomas</dc:contributor> <dc:creator>Goj, Thomas</dc:creator> <dcterms:abstract xml:lang="eng">Nuclear receptors are transcription factors with important functions in a variety of physiological and pathological processes. Targeting glucocorticoid receptor (GR) activity using glucocorticoids is a cornerstone in the treatment of patients with T cell acute lymphoblastic leukemia (T-ALL), and resistance to GC-induced cell death is associated with poor outcome and a high risk for relapse. Next to ligand-binding, heterodimerization with other transcription factors presents an important mechanism for the regulation of GR activity. Here, we describe a GC-induced direct association of the Liver Receptor Homolog-1 (LRH-1) with the GR in the nucleus, which results in reciprocal inhibition of transcriptional activity. Pharmacological and molecular interference with LRH-1 impairs proliferation and survival in T-ALL and causes a profound sensitization to GC-induced cell death, even in GC-resistant T-ALL. Our data illustrate that direct interaction between GR and LRH-1 critically regulates glucocorticoid sensitivity in T-ALL opening up new perspectives for developing innovative therapeutic approaches to treat GC-resistant T-ALL.</dcterms:abstract> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-07-08T12:23:06Z</dcterms:available> <dc:contributor>Bornhauser, Beat</dc:contributor> <dc:contributor>Michalek, Svenja</dc:contributor> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57992/1/Michalek_2-1a7qvw8u2licn6.pdf"/> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57992/1/Michalek_2-1a7qvw8u2licn6.pdf"/> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57992"/> <dc:creator>Marovca, Blerim</dc:creator> <dc:rights>Attribution-NonCommercial-NoDerivatives 4.0 International</dc:rights> <dc:creator>Brunner, Thomas</dc:creator> <dcterms:issued>2022-09-05</dcterms:issued> <dc:contributor>Marovca, Blerim</dc:contributor> <dc:contributor>Plazzo, Anna Pia</dc:contributor> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by-nc-nd/4.0/"/> <dc:creator>Bornhauser, Beat</dc:creator> <dc:language>eng</dc:language> <dc:creator>Plazzo, Anna Pia</dc:creator> <dcterms:title>LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance</dcterms:title> <dc:creator>Michalek, Svenja</dc:creator> </rdf:Description> </rdf:RDF>

Downloads since Jul 8, 2022 (Information about access statistics)

Michalek_2-1a7qvw8u2licn6.pdf 8

This item appears in the following Collection(s)

Attribution-NonCommercial-NoDerivatives 4.0 International Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivatives 4.0 International

Search KOPS


Browse

My Account