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Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox

Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox

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LAL, Avantika, Mariana GALVAO FERRARINI, Andreas J. GRUBER, 2022. Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox. In: Viruses. MDPI. 14(7), 1436. eISSN 1999-4915. Available under: doi: 10.3390/v14071436

@article{Lal2022-07Inves-57989, title={Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox}, year={2022}, doi={10.3390/v14071436}, number={7}, volume={14}, journal={Viruses}, author={Lal, Avantika and Galvao Ferrarini, Mariana and Gruber, Andreas J.}, note={Article Number: 1436} }

<rdf:RDF xmlns:dcterms="http://purl.org/dc/terms/" xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" xmlns:bibo="http://purl.org/ontology/bibo/" xmlns:dspace="http://digital-repositories.org/ontologies/dspace/0.1.0#" xmlns:foaf="http://xmlns.com/foaf/0.1/" xmlns:void="http://rdfs.org/ns/void#" xmlns:xsd="http://www.w3.org/2001/XMLSchema#" > <rdf:Description rdf:about="https://kops.uni-konstanz.de/rdf/resource/123456789/57989"> <dcterms:hasPart rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57989/1/Lal_2-1c9lkx9gs9w8f3.pdf"/> <dcterms:rights rdf:resource="http://creativecommons.org/licenses/by/4.0/"/> <dc:contributor>Lal, Avantika</dc:contributor> <dc:creator>Galvao Ferrarini, Mariana</dc:creator> <dspace:isPartOfCollection rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <dcterms:isPartOf rdf:resource="https://kops.uni-konstanz.de/rdf/resource/123456789/28"/> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dcterms:title>Investigating the Human Host—ssRNA Virus Interaction Landscape Using the SMEAGOL Toolbox</dcterms:title> <dcterms:available rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-07-08T11:29:54Z</dcterms:available> <dc:language>eng</dc:language> <dc:date rdf:datatype="http://www.w3.org/2001/XMLSchema#dateTime">2022-07-08T11:29:54Z</dc:date> <dc:contributor>Galvao Ferrarini, Mariana</dc:contributor> <bibo:uri rdf:resource="https://kops.uni-konstanz.de/handle/123456789/57989"/> <dspace:hasBitstream rdf:resource="https://kops.uni-konstanz.de/bitstream/123456789/57989/1/Lal_2-1c9lkx9gs9w8f3.pdf"/> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Lal, Avantika</dc:creator> <dc:creator>Gruber, Andreas J.</dc:creator> <dcterms:abstract xml:lang="eng">Viruses have evolved numerous mechanisms to exploit the molecular machinery of their host cells, including the broad spectrum of host RNA-binding proteins (RBPs). However, the RBP interactomes of most viruses are largely unknown. To shed light on the interaction landscape of RNA viruses with human host cell RBPs, we have analysed 197 single-stranded RNA (ssRNA) viral genome sequences and found that the majority of ssRNA virus genomes are significantly enriched or depleted in motifs for specific human RBPs, suggesting selection pressure on these interactions. To facilitate tailored investigations and the analysis of genomes sequenced in future, we have released our methodology as a fast and user-friendly computational toolbox named SMEAGOL. Our resources will contribute to future studies of specific ssRNA virus—host cell interactions and support the identification of antiviral drug targets.</dcterms:abstract> <dc:rights>Attribution 4.0 International</dc:rights> <dc:contributor>Gruber, Andreas J.</dc:contributor> <dcterms:issued>2022-07</dcterms:issued> </rdf:Description> </rdf:RDF>

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