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Replacement of animal testing by integrated approaches to testing and assessment (IATA) : a call for in vivitrosi

Replacement of animal testing by integrated approaches to testing and assessment (IATA) : a call for in vivitrosi

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CALONI, Francesca, Isabella DE ANGELIS, Thomas HARTUNG, 2022. Replacement of animal testing by integrated approaches to testing and assessment (IATA) : a call for in vivitrosi. In: Archives of Toxicology. Springer. 96(7), pp. 1935-1950. ISSN 0370-8497. eISSN 1432-0738. Available under: doi: 10.1007/s00204-022-03299-x

@article{Caloni2022-07Repla-57644, title={Replacement of animal testing by integrated approaches to testing and assessment (IATA) : a call for in vivitrosi}, year={2022}, doi={10.1007/s00204-022-03299-x}, number={7}, volume={96}, issn={0370-8497}, journal={Archives of Toxicology}, pages={1935--1950}, author={Caloni, Francesca and De Angelis, Isabella and Hartung, Thomas} }

Replacement of animal testing by integrated approaches to testing and assessment (IATA) : a call for in vivitrosi 2022-05-25T07:26:25Z Hartung, Thomas Caloni, Francesca 2022-05-25T07:26:25Z De Angelis, Isabella eng De Angelis, Isabella Caloni, Francesca Attribution 4.0 International Hartung, Thomas Alternative methods to animal use in toxicology are evolving with new advanced tools and multilevel approaches, to answer from one side to 3Rs requirements, and on the other side offering relevant and valid tests for drugs and chemicals, considering also their combination in test strategies, for a proper risk assessment.<br /><br />While stand-alone methods, have demonstrated to be applicable for some specific toxicological predictions with some limitations, the new strategy for the application of New Approach Methods (NAM), to solve complex toxicological endpoints is addressed by Integrated Approaches for Testing and Assessment (IATA), aka Integrated Testing Strategies (ITS) or Defined Approaches for Testing and Assessment (DA). The central challenge of evidence integration is shared with the needs of risk assessment and systematic reviews of an evidence-based Toxicology. Increasingly, machine learning (aka Artificial Intelligence, AI) lends itself to integrate diverse evidence streams.<br /><br />In this article, we give an overview of the state of the art of alternative methods and IATA in toxicology for regulatory use for various hazards, outlining future orientation and perspectives. We call on leveraging the synergies of integrated approaches and evidence integration from in vivo, in vitro and in silico as true in vivitrosi. 2022-07

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