Crystal structure of SFPQ-NONO heterodimer

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SCHELL, Bianca, Pierre LEGRAND, Sébastien FRIBOURG, 2022. Crystal structure of SFPQ-NONO heterodimer. In: Biochimie. Elsevier. 198, pp. 1-7. ISSN 0300-9084. eISSN 1638-6183. Available under: doi: 10.1016/j.biochi.2022.02.011

@article{Schell2022-03-01Cryst-57500, title={Crystal structure of SFPQ-NONO heterodimer}, year={2022}, doi={10.1016/j.biochi.2022.02.011}, volume={198}, issn={0300-9084}, journal={Biochimie}, pages={1--7}, author={Schell, Bianca and Legrand, Pierre and Fribourg, Sébastien} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:title>Crystal structure of SFPQ-NONO heterodimer</dcterms:title> <dc:contributor>Fribourg, Sébastien</dc:contributor> <dcterms:issued>2022-03-01</dcterms:issued> <dc:contributor>Schell, Bianca</dc:contributor> <dcterms:available rdf:datatype="">2022-05-11T12:43:46Z</dcterms:available> <dc:date rdf:datatype="">2022-05-11T12:43:46Z</dc:date> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dc:creator>Schell, Bianca</dc:creator> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dc:creator>Legrand, Pierre</dc:creator> <dc:language>eng</dc:language> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Fribourg, Sébastien</dc:creator> <dcterms:abstract xml:lang="eng">The Drosophila behavior/human splicing (DBHS) protein family is composed of the three members SFPQ, NONO and PSPC1. These proteins share a strong sequence and structural homology within the core-structured domains forming obligate homo- and heterodimers. This feature may lead to the simultaneous existence of six different dimeric complexes that sustain their function in many cellular processes such as pre-mRNA splicing, innate immunity, transcriptional regulation. In order to perform a complete structural analysis of all possible DBHS dimers, we have solved the crystal structure of the missing DBHS heterodimer SFPQ-NONO at 3.0 Å resolution. We identify subtle changes in amino acid composition and local secondary structure of the NOPS region orientation that may modulate affinity between complexes. Interestingly this area is found mutated in aggressive skin cancers and adenocarcinomas.</dcterms:abstract> <bibo:uri rdf:resource=""/> <dc:contributor>Legrand, Pierre</dc:contributor> <dspace:isPartOfCollection rdf:resource=""/> </rdf:Description> </rdf:RDF>

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