Caspase-1 is a novel target of p63 in tumor suppression

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CELARDO, Ivana, Francesca GRESPI, Alexey ANTONOV, Francesca BERNASSOLA, Alexander V. GARABADGIU, Gerry MELINO, Ivano AMELIO, 2013. Caspase-1 is a novel target of p63 in tumor suppression. In: Cell death & disease. Nature Publishing Group. 4, e645. eISSN 2041-4889. Available under: doi: 10.1038/cddis.2013.175

@article{Celardo2013-05-23Caspa-57122, title={Caspase-1 is a novel target of p63 in tumor suppression}, year={2013}, doi={10.1038/cddis.2013.175}, volume={4}, journal={Cell death & disease}, author={Celardo, Ivana and Grespi, Francesca and Antonov, Alexey and Bernassola, Francesca and Garabadgiu, Alexander V. and Melino, Gerry and Amelio, Ivano}, note={Article Number: e645} }

<rdf:RDF xmlns:dcterms="" xmlns:dc="" xmlns:rdf="" xmlns:bibo="" xmlns:dspace="" xmlns:foaf="" xmlns:void="" xmlns:xsd="" > <rdf:Description rdf:about=""> <dcterms:isPartOf rdf:resource=""/> <dc:creator>Garabadgiu, Alexander V.</dc:creator> <dspace:hasBitstream rdf:resource=""/> <dc:contributor>Melino, Gerry</dc:contributor> <dc:contributor>Amelio, Ivano</dc:contributor> <dc:contributor>Garabadgiu, Alexander V.</dc:contributor> <dc:creator>Melino, Gerry</dc:creator> <foaf:homepage rdf:resource="http://localhost:8080/jspui"/> <dspace:isPartOfCollection rdf:resource=""/> <dc:date rdf:datatype="">2022-03-31T13:32:40Z</dc:date> <dcterms:issued>2013-05-23</dcterms:issued> <dc:creator>Grespi, Francesca</dc:creator> <dc:contributor>Bernassola, Francesca</dc:contributor> <bibo:uri rdf:resource=""/> <dc:contributor>Celardo, Ivana</dc:contributor> <dc:creator>Bernassola, Francesca</dc:creator> <dc:creator>Antonov, Alexey</dc:creator> <dc:language>eng</dc:language> <dc:creator>Amelio, Ivano</dc:creator> <dcterms:available rdf:datatype="">2022-03-31T13:32:40Z</dcterms:available> <void:sparqlEndpoint rdf:resource="http://localhost/fuseki/dspace/sparql"/> <dcterms:rights rdf:resource=""/> <dc:rights>terms-of-use</dc:rights> <dc:creator>Celardo, Ivana</dc:creator> <dc:contributor>Antonov, Alexey</dc:contributor> <dcterms:abstract xml:lang="eng">p63 is a p53 family transcription factor, which besides unique roles in epithelial development, shares tumor suppressive activity with its homolog p53. The p63 gene has different transcriptional start sites, which generate two N-terminal isoforms (transactivation domain (TA)p63 and amino terminal truncated protein(ΔN)p63); in addition alternative splicing at the 5'-end give rise to at least five C-terminal isoforms. This complexity of gene structure has probably fostered the debate and controversy on p63 function in cancer, with TP63-harboring two distinctive promoters, codifying for the TAp63 and ΔNp63 isoforms, and having discrete functions. However, ΔNp63 also drives expression of target genes that have a relevant role in cancer and metastasis. In this study, we identified a novel p63 transcriptional target, caspase-1. Caspase-1 is proinflammatory caspase, which functions in tumor suppression. We show that both p63 isoforms promote caspase-1 expression by physical binding to its promoter. Consistent with our in vitro findings, we also identified a direct correlation between p63 and caspase-1 expression in human cancer data sets. In addition, survival estimation analysis demonstrated that functional interaction between p63 and caspase-1 represents a predictor of positive survival outcome in human cancers. Overall, our data report a novel p63 target gene involved in tumor suppression, and the clinical analysis underlines the biological relevance of this finding and suggests a further clinically predictive biomarker.</dcterms:abstract> <dcterms:title>Caspase-1 is a novel target of p63 in tumor suppression</dcterms:title> <dc:contributor>Grespi, Francesca</dc:contributor> <dcterms:hasPart rdf:resource=""/> </rdf:Description> </rdf:RDF>

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